Therapeutic effects of physostigmine during systemic inflammation

Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction: Usually, physostigmine is used as antidote...

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Autores principales:	Effenberger-Neidnicht K, Jägers J, Verhaegh R, Kirsch M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Sepsis/septic shock – lipopolysaccharide – peripheral blood flow – mean arterial blood pressure – volume load – eserine– rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c9c7f94bbb89450a839cbe4c6d2aba92
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spelling	oai:doaj.org-article:c9c7f94bbb89450a839cbe4c6d2aba922021-12-02T07:23:27ZTherapeutic effects of physostigmine during systemic inflammation1178-7031https://doaj.org/article/c9c7f94bbb89450a839cbe4c6d2aba922018-12-01T00:00:00Zhttps://www.dovepress.com/therapeutic-effects-of-physostigmine-during-systemic-inflammation-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction: Usually, physostigmine is used as antidote for anticholinergic poisons in order to improve hemodynamics and cardiac output. In addition, it causes beneficial effects during sepsis when added timely. Here, we studied whether physostigmine improves hemodynamics when treatment during systemic inflammation was delayed. Methods: Two series of randomized studies with overall 44 rats were conducted. Systemic inflammation was induced by lipopolysaccharide (LPS) infusion (0.5 mg LPS/kg×h). Physostigmine (PHY) was intravenously applied after an LPS infusion period of 90 minutes (50 µg PHY/kg within 10 minutes) with (series 1) and without (series 2) additional volume loading. Hemodynamic parameters, blood gases, and parameters for tissue damage were periodically determined for up to 180 minutes. Results: Even though volume was additionally administered (series 1), LPS caused a reduction of peripheral blood flow. Treatment with PHY improved hemodynamics in macrocirculation (mean arterial blood pressure) and microcirculation (peripheral blood flow). PHY neither affected alterations in blood gases, electrolyte homeostasis, and glucose metabolism nor prevented intestinal damage induced by LPS. In series 2, without any additional volume loading, PHY likewise resulted in an improvement of the LPS-induced alterations in macro- and microcirculation, but finally worsened the LPS-mediated effects on plasma parameters for tissue damage such as creatine kinase, probably due to the lack of volume and a further damage to the heart. Conclusion: The present results demonstrated that hemodynamic responses to PHY may not only be visible in patients with anticholinergic drug overdose but also be visible in septic patients, provided that fluid intake of these patients is adequate. Keywords: sepsis, septic shock, lipopolysaccharide, peripheral blood flow, mean arterial blood pressure, volume load, serine, ratEffenberger-Neidnicht KJägers JVerhaegh RKirsch MDove Medical PressarticleSepsis/septic shock – lipopolysaccharide – peripheral blood flow – mean arterial blood pressure – volume load – eserine– rat.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 465-475 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sepsis/septic shock – lipopolysaccharide – peripheral blood flow – mean arterial blood pressure – volume load – eserine– rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Sepsis/septic shock – lipopolysaccharide – peripheral blood flow – mean arterial blood pressure – volume load – eserine– rat. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Effenberger-Neidnicht K Jägers J Verhaegh R Kirsch M Therapeutic effects of physostigmine during systemic inflammation
description	Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction: Usually, physostigmine is used as antidote for anticholinergic poisons in order to improve hemodynamics and cardiac output. In addition, it causes beneficial effects during sepsis when added timely. Here, we studied whether physostigmine improves hemodynamics when treatment during systemic inflammation was delayed. Methods: Two series of randomized studies with overall 44 rats were conducted. Systemic inflammation was induced by lipopolysaccharide (LPS) infusion (0.5 mg LPS/kg×h). Physostigmine (PHY) was intravenously applied after an LPS infusion period of 90 minutes (50 µg PHY/kg within 10 minutes) with (series 1) and without (series 2) additional volume loading. Hemodynamic parameters, blood gases, and parameters for tissue damage were periodically determined for up to 180 minutes. Results: Even though volume was additionally administered (series 1), LPS caused a reduction of peripheral blood flow. Treatment with PHY improved hemodynamics in macrocirculation (mean arterial blood pressure) and microcirculation (peripheral blood flow). PHY neither affected alterations in blood gases, electrolyte homeostasis, and glucose metabolism nor prevented intestinal damage induced by LPS. In series 2, without any additional volume loading, PHY likewise resulted in an improvement of the LPS-induced alterations in macro- and microcirculation, but finally worsened the LPS-mediated effects on plasma parameters for tissue damage such as creatine kinase, probably due to the lack of volume and a further damage to the heart. Conclusion: The present results demonstrated that hemodynamic responses to PHY may not only be visible in patients with anticholinergic drug overdose but also be visible in septic patients, provided that fluid intake of these patients is adequate. Keywords: sepsis, septic shock, lipopolysaccharide, peripheral blood flow, mean arterial blood pressure, volume load, serine, rat
format	article
author	Effenberger-Neidnicht K Jägers J Verhaegh R Kirsch M
author_facet	Effenberger-Neidnicht K Jägers J Verhaegh R Kirsch M
author_sort	Effenberger-Neidnicht K
title	Therapeutic effects of physostigmine during systemic inflammation
title_short	Therapeutic effects of physostigmine during systemic inflammation
title_full	Therapeutic effects of physostigmine during systemic inflammation
title_fullStr	Therapeutic effects of physostigmine during systemic inflammation
title_full_unstemmed	Therapeutic effects of physostigmine during systemic inflammation
title_sort	therapeutic effects of physostigmine during systemic inflammation
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c9c7f94bbb89450a839cbe4c6d2aba92
work_keys_str_mv	AT effenbergerneidnichtk therapeuticeffectsofphysostigmineduringsystemicinflammation AT jagersj therapeuticeffectsofphysostigmineduringsystemicinflammation AT verhaeghr therapeuticeffectsofphysostigmineduringsystemicinflammation AT kirschm therapeuticeffectsofphysostigmineduringsystemicinflammation
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Therapeutic effects of physostigmine during systemic inflammation

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