Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome

Aim. To assess the safety and efficacy of assisted reproductive technology (ART) programs in patients with systemic lupus erythematosus (SLE) with/without comorbid antiphospholipid syndrome (APLS). Materials and methods. The observational study included 26 patients with diagnosed SLE, of whom 7 w...

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Autores principales:	Galina A. Vlasova, Svetlana G. Perminova, Nadezhda M. Kosheleva
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	systemic lupus erythematosus antiphospholipid syndrome fertility infertility assisted reproductive technologies Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/c9ca33362b8247c299c2c5c31d4ba8fe
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spelling	oai:doaj.org-article:c9ca33362b8247c299c2c5c31d4ba8fe2021-12-02T19:22:24ZApproaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome2079-56962079-583110.26442/20795696.2021.2.200739https://doaj.org/article/c9ca33362b8247c299c2c5c31d4ba8fe2021-05-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/71024/51879https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To assess the safety and efficacy of assisted reproductive technology (ART) programs in patients with systemic lupus erythematosus (SLE) with/without comorbid antiphospholipid syndrome (APLS). Materials and methods. The observational study included 26 patients with diagnosed SLE, of whom 7 women had comorbid APLS and disorders of reproductive function. The analysis of the causes of impaired fertility was based on history and comprehensive examination data, which, along with risk factors for possible complications, determined the choice of ART programs. Results. In 23 of 26 patients, infertility (primary: 14, secondary: 9) was diagnosed, and 3 patients were diagnosed with repeated miscarriage. The main etiological factors of infertility were tubal (n=6), male (n=8) and their combination (n=3); in 9 cases the etiology of infertility remained unclear. 10 patients with a history of lupus nephritis had a reduced ovarian reserve. In total, 23 infertile patients underwent 33 in vitro fertilization programs. 11 (33%) clinical pregnancies were registered, of which 7 ended in live birth. There were no cases of severe exacerbation of SLE and thrombotic complications. Conclusion. ART can be used in patients with SLE with / without APLS, if the underlying disease is compensated for and prevention for complications is used. The effectiveness of ART programs is comparable to that in the general population. Further research is needed to make a final judgment on the safety of various ART programs in SLE with/without APLS.Galina A. VlasovaSvetlana G. PerminovaNadezhda M. KoshelevaIP Berlin A.V. articlesystemic lupus erythematosusantiphospholipid syndromefertilityinfertilityassisted reproductive technologiesGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 2, Pp 167-172 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	systemic lupus erythematosus antiphospholipid syndrome fertility infertility assisted reproductive technologies Gynecology and obstetrics RG1-991
spellingShingle	systemic lupus erythematosus antiphospholipid syndrome fertility infertility assisted reproductive technologies Gynecology and obstetrics RG1-991 Galina A. Vlasova Svetlana G. Perminova Nadezhda M. Kosheleva Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
description	Aim. To assess the safety and efficacy of assisted reproductive technology (ART) programs in patients with systemic lupus erythematosus (SLE) with/without comorbid antiphospholipid syndrome (APLS). Materials and methods. The observational study included 26 patients with diagnosed SLE, of whom 7 women had comorbid APLS and disorders of reproductive function. The analysis of the causes of impaired fertility was based on history and comprehensive examination data, which, along with risk factors for possible complications, determined the choice of ART programs. Results. In 23 of 26 patients, infertility (primary: 14, secondary: 9) was diagnosed, and 3 patients were diagnosed with repeated miscarriage. The main etiological factors of infertility were tubal (n=6), male (n=8) and their combination (n=3); in 9 cases the etiology of infertility remained unclear. 10 patients with a history of lupus nephritis had a reduced ovarian reserve. In total, 23 infertile patients underwent 33 in vitro fertilization programs. 11 (33%) clinical pregnancies were registered, of which 7 ended in live birth. There were no cases of severe exacerbation of SLE and thrombotic complications. Conclusion. ART can be used in patients with SLE with / without APLS, if the underlying disease is compensated for and prevention for complications is used. The effectiveness of ART programs is comparable to that in the general population. Further research is needed to make a final judgment on the safety of various ART programs in SLE with/without APLS.
format	article
author	Galina A. Vlasova Svetlana G. Perminova Nadezhda M. Kosheleva
author_facet	Galina A. Vlasova Svetlana G. Perminova Nadezhda M. Kosheleva
author_sort	Galina A. Vlasova
title	Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
title_short	Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
title_full	Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
title_fullStr	Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
title_full_unstemmed	Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
title_sort	approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/c9ca33362b8247c299c2c5c31d4ba8fe
work_keys_str_mv	AT galinaavlasova approachestotherealizationofreproductivefunctioninwomenwithsystemiclupuserythematosusandantiphospholipidsyndrome AT svetlanagperminova approachestotherealizationofreproductivefunctioninwomenwithsystemiclupuserythematosusandantiphospholipidsyndrome AT nadezhdamkosheleva approachestotherealizationofreproductivefunctioninwomenwithsystemiclupuserythematosusandantiphospholipidsyndrome
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Approaches to the realization of reproductive function in women with systemic lupus erythematosus and antiphospholipid syndrome

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