Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation

Abstract Uterine inflammation is a very common and serious condition in domestic animals. To development and progression of this pathology often lead disturbances in myometrial contractility. Participation of β1-, β2- and β3-adrenergic receptors (ARs) in noradrenaline (NA)-influenced contractility o...

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Autores principales:	Barbara Jana, Jarosław Całka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9ca349e96ac44648a48b106eee9a998
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spelling	oai:doaj.org-article:c9ca349e96ac44648a48b106eee9a9982021-12-02T15:02:31ZRole of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation10.1038/s41598-021-91184-52045-2322https://doaj.org/article/c9ca349e96ac44648a48b106eee9a9982021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91184-5https://doaj.org/toc/2045-2322Abstract Uterine inflammation is a very common and serious condition in domestic animals. To development and progression of this pathology often lead disturbances in myometrial contractility. Participation of β1-, β2- and β3-adrenergic receptors (ARs) in noradrenaline (NA)-influenced contractility of the pig inflamed uterus was studied. The gilts of SAL- and E.coli-treated groups were administered saline or E.coli suspension into the uterine horns, respectively. Laparotomy was only done in the CON group. Compared to the period before NA administration, this neurotransmitter reduced the tension, amplitude and frequency in uterine strips of the CON and SAL groups. In the E.coli group, NA decreased the amplitude and frequency, and these parameters were lower than in other groups. In the CON, SAL and E.coli groups, β1- and β3-ARs antagonists in more cases did not significantly change and partly eliminated NA inhibitory effect on amplitude and frequency, as compared to NA action alone. In turn, β2-ARs antagonist completely abolished NA relaxatory effect on these parameters in three groups. Summarizing, NA decreases the contractile amplitude and frequency of pig inflamed uterus via all β-ARs subtypes, however, β2-ARs have the greatest importance. Given this, pharmacological modulation of particular β-ARs subtypes can be used to increase inflamed uterus contractility.Barbara JanaJarosław CałkaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Barbara Jana Jarosław Całka Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
description	Abstract Uterine inflammation is a very common and serious condition in domestic animals. To development and progression of this pathology often lead disturbances in myometrial contractility. Participation of β1-, β2- and β3-adrenergic receptors (ARs) in noradrenaline (NA)-influenced contractility of the pig inflamed uterus was studied. The gilts of SAL- and E.coli-treated groups were administered saline or E.coli suspension into the uterine horns, respectively. Laparotomy was only done in the CON group. Compared to the period before NA administration, this neurotransmitter reduced the tension, amplitude and frequency in uterine strips of the CON and SAL groups. In the E.coli group, NA decreased the amplitude and frequency, and these parameters were lower than in other groups. In the CON, SAL and E.coli groups, β1- and β3-ARs antagonists in more cases did not significantly change and partly eliminated NA inhibitory effect on amplitude and frequency, as compared to NA action alone. In turn, β2-ARs antagonist completely abolished NA relaxatory effect on these parameters in three groups. Summarizing, NA decreases the contractile amplitude and frequency of pig inflamed uterus via all β-ARs subtypes, however, β2-ARs have the greatest importance. Given this, pharmacological modulation of particular β-ARs subtypes can be used to increase inflamed uterus contractility.
format	article
author	Barbara Jana Jarosław Całka
author_facet	Barbara Jana Jarosław Całka
author_sort	Barbara Jana
title	Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
title_short	Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
title_full	Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
title_fullStr	Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
title_full_unstemmed	Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
title_sort	role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9ca349e96ac44648a48b106eee9a998
work_keys_str_mv	AT barbarajana roleofbetaadrenergicreceptorsubtypesinpiguteruscontractilitywithinflammation AT jarosławcałka roleofbetaadrenergicreceptorsubtypesinpiguteruscontractilitywithinflammation
_version_	1718389103886598144

Role of beta-adrenergic receptor subtypes in pig uterus contractility with inflammation

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