Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis

Introduction: Incidence of acute pancreatitis (AP) varies in different parts of the world. The published data are mainly based on retrospective analysis of hospital admissions, which show that there are considerable geographical differences in the incidence rate. There are also regional divergences...

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Autores principales: Abhishek Bhattarai, Pragya Devkota, Bishu Prasad Kandel, Bikal Ghimire, Prasan Bir Singh Kansakar, Ramesh Singh Bhandari, Kishor Kumar Tamrakar, Palaswan Joshi Lakhey, Parshuram Mishra, Yogendra Prasad Singh, Pradeep Vaidya, Keshaw Prasad Singh
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Publicado: Society of Surgeons of Nepal 2017
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spelling oai:doaj.org-article:c9cabdf8746f4f44bcd5e6a83a6bc86a2021-12-05T19:16:11ZComparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis10.3126/jssn.v20i1.245371815-39842392-4772https://doaj.org/article/c9cabdf8746f4f44bcd5e6a83a6bc86a2017-06-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/24537https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction: Incidence of acute pancreatitis (AP) varies in different parts of the world. The published data are mainly based on retrospective analysis of hospital admissions, which show that there are considerable geographical differences in the incidence rate. There are also regional divergences with regard to the etiology, and its impact on morbidity and mortality. Therefore, we compare the clinical course of acute biliary and non-biliary pancreatitis at the Tribhuvan University Teaching Hospital (TUTH) as well as we compare the morbidity and mortality and duration of hospital stay in these groups. Methods: This prospective study included the patients with a diagnosis of AP over a period of one year. Eighty-five patients with the diagnosis of AP were included in the study. Revised Atlanta classification system (2012) was used to diagnose and define the severity of disease. The occurrence of local and systemic complications, median duration of hospital stay and mortality in AP was studied. Results: Among 85 patients, 34 patients were females and 51 were males. Among them, 46 patients belonged to the biliary group and 39 belonged to the non-biliary group. Alcohol intake was the major etiology in the non-biliary group (n = 26) and all of them were male. The majority of the gallstone induced AP patients were female (n = 29). Twenty-nine patients developed severe acute pancreatitis (SAP: 16 in biliary and 13 patients in non-biliary group). Complications were mostly seen in SAP. The acute fluid collection was the most common local complication (15 patients in biliary and 15 patients in non-biliary group, p > 0.05) and respiratory failure was the most common systemic complication (18 patients in biliary and 16 patients in non-biliary group, p > 0.05) in both groups. Three patients in biliary group and four patients in non-biliary group died due to multi-organ failure (p > 0.05). There was no statistical significant difference in the median duration of hospital stay in these groups. Conclusion: Though pathogenesis vary for different etiologies, once the disease process has started, local complications, systemic complications, duration of hospital stay and mortality in AP depends on the severity of the disease irrespective of the etiology. Abhishek BhattaraiPragya DevkotaBishu Prasad KandelBikal GhimirePrasan Bir Singh KansakarRamesh Singh BhandariKishor Kumar TamrakarPalaswan Joshi LakheyParshuram MishraYogendra Prasad SinghPradeep VaidyaKeshaw Prasad SinghSociety of Surgeons of NepalarticleAcute PancreatitisBiliary PancreatitisNon-Biliary PancreatitisSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 20, Iss 1 (2017)
institution DOAJ
collection DOAJ
language EN
topic Acute Pancreatitis
Biliary Pancreatitis
Non-Biliary Pancreatitis
Surgery
RD1-811
spellingShingle Acute Pancreatitis
Biliary Pancreatitis
Non-Biliary Pancreatitis
Surgery
RD1-811
Abhishek Bhattarai
Pragya Devkota
Bishu Prasad Kandel
Bikal Ghimire
Prasan Bir Singh Kansakar
Ramesh Singh Bhandari
Kishor Kumar Tamrakar
Palaswan Joshi Lakhey
Parshuram Mishra
Yogendra Prasad Singh
Pradeep Vaidya
Keshaw Prasad Singh
Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
description Introduction: Incidence of acute pancreatitis (AP) varies in different parts of the world. The published data are mainly based on retrospective analysis of hospital admissions, which show that there are considerable geographical differences in the incidence rate. There are also regional divergences with regard to the etiology, and its impact on morbidity and mortality. Therefore, we compare the clinical course of acute biliary and non-biliary pancreatitis at the Tribhuvan University Teaching Hospital (TUTH) as well as we compare the morbidity and mortality and duration of hospital stay in these groups. Methods: This prospective study included the patients with a diagnosis of AP over a period of one year. Eighty-five patients with the diagnosis of AP were included in the study. Revised Atlanta classification system (2012) was used to diagnose and define the severity of disease. The occurrence of local and systemic complications, median duration of hospital stay and mortality in AP was studied. Results: Among 85 patients, 34 patients were females and 51 were males. Among them, 46 patients belonged to the biliary group and 39 belonged to the non-biliary group. Alcohol intake was the major etiology in the non-biliary group (n = 26) and all of them were male. The majority of the gallstone induced AP patients were female (n = 29). Twenty-nine patients developed severe acute pancreatitis (SAP: 16 in biliary and 13 patients in non-biliary group). Complications were mostly seen in SAP. The acute fluid collection was the most common local complication (15 patients in biliary and 15 patients in non-biliary group, p > 0.05) and respiratory failure was the most common systemic complication (18 patients in biliary and 16 patients in non-biliary group, p > 0.05) in both groups. Three patients in biliary group and four patients in non-biliary group died due to multi-organ failure (p > 0.05). There was no statistical significant difference in the median duration of hospital stay in these groups. Conclusion: Though pathogenesis vary for different etiologies, once the disease process has started, local complications, systemic complications, duration of hospital stay and mortality in AP depends on the severity of the disease irrespective of the etiology.
format article
author Abhishek Bhattarai
Pragya Devkota
Bishu Prasad Kandel
Bikal Ghimire
Prasan Bir Singh Kansakar
Ramesh Singh Bhandari
Kishor Kumar Tamrakar
Palaswan Joshi Lakhey
Parshuram Mishra
Yogendra Prasad Singh
Pradeep Vaidya
Keshaw Prasad Singh
author_facet Abhishek Bhattarai
Pragya Devkota
Bishu Prasad Kandel
Bikal Ghimire
Prasan Bir Singh Kansakar
Ramesh Singh Bhandari
Kishor Kumar Tamrakar
Palaswan Joshi Lakhey
Parshuram Mishra
Yogendra Prasad Singh
Pradeep Vaidya
Keshaw Prasad Singh
author_sort Abhishek Bhattarai
title Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
title_short Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
title_full Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
title_fullStr Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
title_full_unstemmed Comparison of clinical course of Acute Biliary and Non-Biliary Pancreatitis
title_sort comparison of clinical course of acute biliary and non-biliary pancreatitis
publisher Society of Surgeons of Nepal
publishDate 2017
url https://doaj.org/article/c9cabdf8746f4f44bcd5e6a83a6bc86a
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