P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

Chimeric antigen receptor (CAR) T cell therapy has been proposed as a promising approach for treating glioblastoma. Here the authors show that p32 is expressed in murine and human glioma and that p32-directed CAR-T cells promote anti-tumor responses in preclinical models by targeting glioma cells an...

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Autores principales:	Liat Rousso-Noori, Ignacio Mastandrea, Shauli Talmor, Tova Waks, Anat Globerson Levin, Maarja Haugas, Tambet Teesalu, Luis Alvarez-Vallina, Zelig Eshhar, Dinorah Friedmann-Morvinski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9d019d611994e5cb582be3f41cb6a8b
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spelling	oai:doaj.org-article:c9d019d611994e5cb582be3f41cb6a8b2021-12-02T17:40:00ZP32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas10.1038/s41467-021-23817-22041-1723https://doaj.org/article/c9d019d611994e5cb582be3f41cb6a8b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23817-2https://doaj.org/toc/2041-1723Chimeric antigen receptor (CAR) T cell therapy has been proposed as a promising approach for treating glioblastoma. Here the authors show that p32 is expressed in murine and human glioma and that p32-directed CAR-T cells promote anti-tumor responses in preclinical models by targeting glioma cells and tumor derived endothelial cells.Liat Rousso-NooriIgnacio MastandreaShauli TalmorTova WaksAnat Globerson LevinMaarja HaugasTambet TeesaluLuis Alvarez-VallinaZelig EshharDinorah Friedmann-MorvinskiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liat Rousso-Noori Ignacio Mastandrea Shauli Talmor Tova Waks Anat Globerson Levin Maarja Haugas Tambet Teesalu Luis Alvarez-Vallina Zelig Eshhar Dinorah Friedmann-Morvinski P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
description	Chimeric antigen receptor (CAR) T cell therapy has been proposed as a promising approach for treating glioblastoma. Here the authors show that p32 is expressed in murine and human glioma and that p32-directed CAR-T cells promote anti-tumor responses in preclinical models by targeting glioma cells and tumor derived endothelial cells.
format	article
author	Liat Rousso-Noori Ignacio Mastandrea Shauli Talmor Tova Waks Anat Globerson Levin Maarja Haugas Tambet Teesalu Luis Alvarez-Vallina Zelig Eshhar Dinorah Friedmann-Morvinski
author_facet	Liat Rousso-Noori Ignacio Mastandrea Shauli Talmor Tova Waks Anat Globerson Levin Maarja Haugas Tambet Teesalu Luis Alvarez-Vallina Zelig Eshhar Dinorah Friedmann-Morvinski
author_sort	Liat Rousso-Noori
title	P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
title_short	P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
title_full	P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
title_fullStr	P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
title_full_unstemmed	P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
title_sort	p32-specific car t cells with dual antitumor and antiangiogenic therapeutic potential in gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9d019d611994e5cb582be3f41cb6a8b
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P32-specific CAR T cells with dual antitumor and antiangiogenic therapeutic potential in gliomas

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