Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

Abstract This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Svetlana Orlova, Galina Dikke, Gisele Pickering, Eliso Djobava, Sofya Konchits, Kirill Starostin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9d422b8b67143309befd478caf9e3c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9d422b8b67143309befd478caf9e3c1
record_format	dspace
spelling	oai:doaj.org-article:c9d422b8b67143309befd478caf9e3c12021-12-02T13:34:33ZMagnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data10.1038/s41598-021-85156-y2045-2322https://doaj.org/article/c9d422b8b67143309befd478caf9e3c12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85156-yhttps://doaj.org/toc/2045-2322Abstract This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes.Svetlana OrlovaGalina DikkeGisele PickeringEliso DjobavaSofya KonchitsKirill StarostinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Svetlana Orlova Galina Dikke Gisele Pickering Eliso Djobava Sofya Konchits Kirill Starostin Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
description	Abstract This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes.
format	article
author	Svetlana Orlova Galina Dikke Gisele Pickering Eliso Djobava Sofya Konchits Kirill Starostin
author_facet	Svetlana Orlova Galina Dikke Gisele Pickering Eliso Djobava Sofya Konchits Kirill Starostin
author_sort	Svetlana Orlova
title	Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
title_short	Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
title_full	Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
title_fullStr	Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
title_full_unstemmed	Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
title_sort	magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9d422b8b67143309befd478caf9e3c1
work_keys_str_mv	AT svetlanaorlova magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata AT galinadikke magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata AT giselepickering magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata AT elisodjobava magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata AT sofyakonchits magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata AT kirillstarostin magnesiumlevelcorrelationwithclinicalstatusandqualityoflifeinwomenwithhormonerelatedconditionsandpregnancybasedonrealworlddata
_version_	1718392760602460160

Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

Ejemplares similares