Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were charac...

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Autores principales:	Ramaraj Sukanya, Karuppaiah Balamurugan, Shen-Ming Chen, Ramachandran Rajakumaran, K. Muthupandi, Jae-Jin Shim, Carmel B. Breslin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ternary metal oxides heterostructure electrochemical sensor secnidazole Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> MPs Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/c9da60fa7f4940e5afa2571b3c1d367d
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spelling	oai:doaj.org-article:c9da60fa7f4940e5afa2571b3c1d367d2021-11-11T18:11:59ZFabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole10.3390/ma142167001996-1944https://doaj.org/article/c9da60fa7f4940e5afa2571b3c1d367d2021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6700https://doaj.org/toc/1996-1944In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.Ramaraj SukanyaKaruppaiah BalamuruganShen-Ming ChenRamachandran RajakumaranK. MuthupandiJae-Jin ShimCarmel B. BreslinMDPI AGarticleternary metal oxidesheterostructureelectrochemical sensorsecnidazoleZn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> MPsTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6700, p 6700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ternary metal oxides heterostructure electrochemical sensor secnidazole Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> MPs Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	ternary metal oxides heterostructure electrochemical sensor secnidazole Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> MPs Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 Ramaraj Sukanya Karuppaiah Balamurugan Shen-Ming Chen Ramachandran Rajakumaran K. Muthupandi Jae-Jin Shim Carmel B. Breslin Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
description	In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.
format	article
author	Ramaraj Sukanya Karuppaiah Balamurugan Shen-Ming Chen Ramachandran Rajakumaran K. Muthupandi Jae-Jin Shim Carmel B. Breslin
author_facet	Ramaraj Sukanya Karuppaiah Balamurugan Shen-Ming Chen Ramachandran Rajakumaran K. Muthupandi Jae-Jin Shim Carmel B. Breslin
author_sort	Ramaraj Sukanya
title	Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
title_short	Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
title_full	Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
title_fullStr	Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
title_full_unstemmed	Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole
title_sort	fabrication of a selective sensor amplification probe modified with multi-component zn<sub>2</sub>sno<sub>4</sub>/sno<sub>2</sub> heterostructured microparticles as a robust electrocatalyst for electrochemical detection of antibacterial drug secnidazole
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c9da60fa7f4940e5afa2571b3c1d367d
work_keys_str_mv	AT ramarajsukanya fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT karuppaiahbalamurugan fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT shenmingchen fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT ramachandranrajakumaran fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT kmuthupandi fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT jaejinshim fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole AT carmelbbreslin fabricationofaselectivesensoramplificationprobemodifiedwithmulticomponentznsub2subsnosub4subsnosub2subheterostructuredmicroparticlesasarobustelectrocatalystforelectrochemicaldetectionofantibacterialdrugsecnidazole
_version_	1718431910728826880

Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn<sub>2</sub>SnO<sub>4</sub>/SnO<sub>2</sub> Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

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