A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge

Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the va...

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Autores principales: Yfat Yahalom-Ronen, Hadas Tamir, Sharon Melamed, Boaz Politi, Ohad Shifman, Hagit Achdout, Einat B. Vitner, Ofir Israeli, Elad Milrot, Dana Stein, Inbar Cohen-Gihon, Shlomi Lazar, Hila Gutman, Itai Glinert, Lilach Cherry, Yaron Vagima, Shirley Lazar, Shay Weiss, Amir Ben-Shmuel, Roy Avraham, Reut Puni, Edith Lupu, Elad Bar-David, Assa Sittner, Noam Erez, Ran Zichel, Emanuelle Mamroud, Ohad Mazor, Haim Levy, Orly Laskar, Shmuel Yitzhaki, Shmuel C. Shapira, Anat Zvi, Adi Beth-Din, Nir Paran, Tomer Israely
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c9dbfd8736364f25b7884f0d5634e9e1
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spelling oai:doaj.org-article:c9dbfd8736364f25b7884f0d5634e9e12021-12-02T14:16:24ZA single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge10.1038/s41467-020-20228-72041-1723https://doaj.org/article/c9dbfd8736364f25b7884f0d5634e9e12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20228-7https://doaj.org/toc/2041-1723Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.Yfat Yahalom-RonenHadas TamirSharon MelamedBoaz PolitiOhad ShifmanHagit AchdoutEinat B. VitnerOfir IsraeliElad MilrotDana SteinInbar Cohen-GihonShlomi LazarHila GutmanItai GlinertLilach CherryYaron VagimaShirley LazarShay WeissAmir Ben-ShmuelRoy AvrahamReut PuniEdith LupuElad Bar-DavidAssa SittnerNoam ErezRan ZichelEmanuelle MamroudOhad MazorHaim LevyOrly LaskarShmuel YitzhakiShmuel C. ShapiraAnat ZviAdi Beth-DinNir ParanTomer IsraelyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yfat Yahalom-Ronen
Hadas Tamir
Sharon Melamed
Boaz Politi
Ohad Shifman
Hagit Achdout
Einat B. Vitner
Ofir Israeli
Elad Milrot
Dana Stein
Inbar Cohen-Gihon
Shlomi Lazar
Hila Gutman
Itai Glinert
Lilach Cherry
Yaron Vagima
Shirley Lazar
Shay Weiss
Amir Ben-Shmuel
Roy Avraham
Reut Puni
Edith Lupu
Elad Bar-David
Assa Sittner
Noam Erez
Ran Zichel
Emanuelle Mamroud
Ohad Mazor
Haim Levy
Orly Laskar
Shmuel Yitzhaki
Shmuel C. Shapira
Anat Zvi
Adi Beth-Din
Nir Paran
Tomer Israely
A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
description Here, the authors generate a replication-competent VSV based vaccine expressing SARS-CoV-2 spike protein and show protection in the hamster model with one dose. Analysis of the antibody response in mice shows induction of neutralizing antibodies and suggests a desirable Th1-biased response to the vaccine.
format article
author Yfat Yahalom-Ronen
Hadas Tamir
Sharon Melamed
Boaz Politi
Ohad Shifman
Hagit Achdout
Einat B. Vitner
Ofir Israeli
Elad Milrot
Dana Stein
Inbar Cohen-Gihon
Shlomi Lazar
Hila Gutman
Itai Glinert
Lilach Cherry
Yaron Vagima
Shirley Lazar
Shay Weiss
Amir Ben-Shmuel
Roy Avraham
Reut Puni
Edith Lupu
Elad Bar-David
Assa Sittner
Noam Erez
Ran Zichel
Emanuelle Mamroud
Ohad Mazor
Haim Levy
Orly Laskar
Shmuel Yitzhaki
Shmuel C. Shapira
Anat Zvi
Adi Beth-Din
Nir Paran
Tomer Israely
author_facet Yfat Yahalom-Ronen
Hadas Tamir
Sharon Melamed
Boaz Politi
Ohad Shifman
Hagit Achdout
Einat B. Vitner
Ofir Israeli
Elad Milrot
Dana Stein
Inbar Cohen-Gihon
Shlomi Lazar
Hila Gutman
Itai Glinert
Lilach Cherry
Yaron Vagima
Shirley Lazar
Shay Weiss
Amir Ben-Shmuel
Roy Avraham
Reut Puni
Edith Lupu
Elad Bar-David
Assa Sittner
Noam Erez
Ran Zichel
Emanuelle Mamroud
Ohad Mazor
Haim Levy
Orly Laskar
Shmuel Yitzhaki
Shmuel C. Shapira
Anat Zvi
Adi Beth-Din
Nir Paran
Tomer Israely
author_sort Yfat Yahalom-Ronen
title A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
title_short A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
title_full A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
title_fullStr A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
title_full_unstemmed A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
title_sort single dose of recombinant vsv-∆g-spike vaccine provides protection against sars-cov-2 challenge
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c9dbfd8736364f25b7884f0d5634e9e1
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