Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

“mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability and Alzheimer’s disease.”

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Autores principales:	Rached Alkallas, Lisa Fish, Hani Goodarzi, Hamed S. Najafabadi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9decdf8979e4cb5bcf04691b5455dd8
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spelling	oai:doaj.org-article:c9decdf8979e4cb5bcf04691b5455dd82021-12-02T17:06:23ZInference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease10.1038/s41467-017-00867-z2041-1723https://doaj.org/article/c9decdf8979e4cb5bcf04691b5455dd82017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00867-zhttps://doaj.org/toc/2041-1723“mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability and Alzheimer’s disease.”Rached AlkallasLisa FishHani GoodarziHamed S. NajafabadiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rached Alkallas Lisa Fish Hani Goodarzi Hamed S. Najafabadi Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
description	“mRNA abundance is determined by the rates of transcription and decay. Here, the authors propose a method for estimating the rate of differential mRNA decay from RNA-seq data and model mRNA stability in the brain, suggesting a link between mRNA stability and Alzheimer’s disease.”
format	article
author	Rached Alkallas Lisa Fish Hani Goodarzi Hamed S. Najafabadi
author_facet	Rached Alkallas Lisa Fish Hani Goodarzi Hamed S. Najafabadi
author_sort	Rached Alkallas
title	Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
title_short	Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
title_full	Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
title_fullStr	Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
title_full_unstemmed	Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
title_sort	inference of rna decay rate from transcriptional profiling highlights the regulatory programs of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c9decdf8979e4cb5bcf04691b5455dd8
work_keys_str_mv	AT rachedalkallas inferenceofrnadecayratefromtranscriptionalprofilinghighlightstheregulatoryprogramsofalzheimersdisease AT lisafish inferenceofrnadecayratefromtranscriptionalprofilinghighlightstheregulatoryprogramsofalzheimersdisease AT hanigoodarzi inferenceofrnadecayratefromtranscriptionalprofilinghighlightstheregulatoryprogramsofalzheimersdisease AT hamedsnajafabadi inferenceofrnadecayratefromtranscriptionalprofilinghighlightstheregulatoryprogramsofalzheimersdisease
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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

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