Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

PAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosph...

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Autores principales:	Yohendran Baskaran, Felicia Pei-Ling Tay, Elsa Yuen Wai Ng, Claire Lee Foon Swa, Sheena Wee, Jayantha Gunaratne, Edward Manser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9e161aeee0b4d8fb9c114a3126f6415
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spelling	oai:doaj.org-article:c9e161aeee0b4d8fb9c114a3126f64152021-12-02T17:41:08ZProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions10.1038/s41467-021-25011-w2041-1723https://doaj.org/article/c9e161aeee0b4d8fb9c114a3126f64152021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25011-whttps://doaj.org/toc/2041-1723PAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosphorylation substrates at this site.Yohendran BaskaranFelicia Pei-Ling TayElsa Yuen Wai NgClaire Lee Foon SwaSheena WeeJayantha GunaratneEdward ManserNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
description	PAK4 is a kinase involved in cell-cell junctions, though the identify of the local protein network involving PAK4 is unclear. Here, the authors performed proximity proteomic analysis on mammalian PAK4 and find that PAK4 is associated with Afadin-dependent junctions, and report putative PAK4 phosphorylation substrates at this site.
format	article
author	Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser
author_facet	Yohendran Baskaran Felicia Pei-Ling Tay Elsa Yuen Wai Ng Claire Lee Foon Swa Sheena Wee Jayantha Gunaratne Edward Manser
author_sort	Yohendran Baskaran
title	Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
title_short	Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
title_full	Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
title_fullStr	Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
title_full_unstemmed	Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions
title_sort	proximity proteomics identifies pak4 as a component of afadin–nectin junctions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9e161aeee0b4d8fb9c114a3126f6415
work_keys_str_mv	AT yohendranbaskaran proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT feliciapeilingtay proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT elsayuenwaing proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT claireleefoonswa proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT sheenawee proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT jayanthagunaratne proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions AT edwardmanser proximityproteomicsidentifiespak4asacomponentofafadinnectinjunctions
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Proximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions

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