A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.

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Autores principales:	Yanfeng Wang, Shaopeng Chi, Huifang Guo, Guang Li, Li Wang, Qiancheng Zhao, Yu Rao, Liansuo Zu, Wei He, Bailong Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c
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id	oai:doaj.org-article:c9e4bf37c751415aba8d06d398c7970c
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spelling	oai:doaj.org-article:c9e4bf37c751415aba8d06d398c7970c2021-12-02T15:34:22ZA lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel10.1038/s41467-018-03570-92041-1723https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03570-9https://doaj.org/toc/2041-1723Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.Yanfeng WangShaopeng ChiHuifang GuoGuang LiLi WangQiancheng ZhaoYu RaoLiansuo ZuWei HeBailong XiaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanfeng Wang Shaopeng Chi Huifang Guo Guang Li Li Wang Qiancheng Zhao Yu Rao Liansuo Zu Wei He Bailong Xiao A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
description	Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.
format	article
author	Yanfeng Wang Shaopeng Chi Huifang Guo Guang Li Li Wang Qiancheng Zhao Yu Rao Liansuo Zu Wei He Bailong Xiao
author_facet	Yanfeng Wang Shaopeng Chi Huifang Guo Guang Li Li Wang Qiancheng Zhao Yu Rao Liansuo Zu Wei He Bailong Xiao
author_sort	Yanfeng Wang
title	A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
title_short	A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
title_full	A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
title_fullStr	A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
title_full_unstemmed	A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
title_sort	lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive piezo1 channel
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c
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A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel

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