A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.
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| Main Authors: | , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
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| Subjects: | |
| Online Access: | https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c |
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