High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis

Abstract There is no known biomarker that predicts the response to immune therapy in autoimmune synaptic encephalitis. Thus, we investigated serum albumin as a prognostic biomarker of early immune therapies in patients with autoimmune encephalitis. We enrolled patients who were diagnosed with defini...

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Autores principales:	Yoonhyuk Jang, Soon-Tae Lee, Tae-Joon Kim, Jin-Sun Jun, Jangsup Moon, Keun-Hwa Jung, Kyung-Il Park, Kon Chu, Sang Kun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9e6c43071504f06bd7bff356d7252fb
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spelling	oai:doaj.org-article:c9e6c43071504f06bd7bff356d7252fb2021-12-02T15:08:56ZHigh albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis10.1038/s41598-018-19490-z2045-2322https://doaj.org/article/c9e6c43071504f06bd7bff356d7252fb2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19490-zhttps://doaj.org/toc/2045-2322Abstract There is no known biomarker that predicts the response to immune therapy in autoimmune synaptic encephalitis. Thus, we investigated serum albumin as a prognostic biomarker of early immune therapies in patients with autoimmune encephalitis. We enrolled patients who were diagnosed with definite autoimmune encephalitis and underwent IVIg treatment at Seoul National University Hospital from 2012 to 2017. Patients were dichotomized according to serum albumin prior to IVIg administration with a cut-off level of 4.0 g/dL, which was the median value of 50% of patients. Seventeen (53.1%) of the 32 patients with definite autoimmune encephalitis who received IVIg treatment in our hospital had low serum albumin (<4.0 g/dL). The initial disease severity (mRS ≥ 4) was the sole factor that predicted low albumin in autoimmune encephalitis patients using multivariate analysis (P = 0.013). The low albumin group exhibited a worse response to immune therapy at the third and fourth weeks from IVIg administration (P < 0.01 and P = 0.012, respectively), and recovery to activities of daily life without assistance was faster in the high albumin group (log-rank test for trend, P < 0.01). Our study found that pretreatment low serum albumin was a significant indicator of autoimmune encephalitis prognosis in the short-term and long-term.Yoonhyuk JangSoon-Tae LeeTae-Joon KimJin-Sun JunJangsup MoonKeun-Hwa JungKyung-Il ParkKon ChuSang Kun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoonhyuk Jang Soon-Tae Lee Tae-Joon Kim Jin-Sun Jun Jangsup Moon Keun-Hwa Jung Kyung-Il Park Kon Chu Sang Kun Lee High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
description	Abstract There is no known biomarker that predicts the response to immune therapy in autoimmune synaptic encephalitis. Thus, we investigated serum albumin as a prognostic biomarker of early immune therapies in patients with autoimmune encephalitis. We enrolled patients who were diagnosed with definite autoimmune encephalitis and underwent IVIg treatment at Seoul National University Hospital from 2012 to 2017. Patients were dichotomized according to serum albumin prior to IVIg administration with a cut-off level of 4.0 g/dL, which was the median value of 50% of patients. Seventeen (53.1%) of the 32 patients with definite autoimmune encephalitis who received IVIg treatment in our hospital had low serum albumin (<4.0 g/dL). The initial disease severity (mRS ≥ 4) was the sole factor that predicted low albumin in autoimmune encephalitis patients using multivariate analysis (P = 0.013). The low albumin group exhibited a worse response to immune therapy at the third and fourth weeks from IVIg administration (P < 0.01 and P = 0.012, respectively), and recovery to activities of daily life without assistance was faster in the high albumin group (log-rank test for trend, P < 0.01). Our study found that pretreatment low serum albumin was a significant indicator of autoimmune encephalitis prognosis in the short-term and long-term.
format	article
author	Yoonhyuk Jang Soon-Tae Lee Tae-Joon Kim Jin-Sun Jun Jangsup Moon Keun-Hwa Jung Kyung-Il Park Kon Chu Sang Kun Lee
author_facet	Yoonhyuk Jang Soon-Tae Lee Tae-Joon Kim Jin-Sun Jun Jangsup Moon Keun-Hwa Jung Kyung-Il Park Kon Chu Sang Kun Lee
author_sort	Yoonhyuk Jang
title	High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
title_short	High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
title_full	High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
title_fullStr	High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
title_full_unstemmed	High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
title_sort	high albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c9e6c43071504f06bd7bff356d7252fb
work_keys_str_mv	AT yoonhyukjang highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT soontaelee highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT taejoonkim highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT jinsunjun highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT jangsupmoon highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT keunhwajung highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT kyungilpark highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT konchu highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis AT sangkunlee highalbuminlevelisapredictoroffavorableresponsetoimmunotherapyinautoimmuneencephalitis
_version_	1718387965111042048

High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis

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