Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.

Insecticides have a variety of commercial applications including urban pest control, agricultural use to increase crop yields, and prevention of proliferation of insect-borne diseases. Many pesticides in current use are synthetic molecules such as organochlorine and organophosphate compounds. Some s...

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Autores principales:	Kaitlin M Baudier, Simon D Kaschock-Marenda, Nirali Patel, Katherine L Diangelus, Sean O'Donnell, Daniel R Marenda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9e9109f40694d258d508be20e1e683b
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spelling	oai:doaj.org-article:c9e9109f40694d258d508be20e1e683b2021-11-18T08:17:14ZErythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.1932-620310.1371/journal.pone.0098949https://doaj.org/article/c9e9109f40694d258d508be20e1e683b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24896294/?tool=EBIhttps://doaj.org/toc/1932-6203Insecticides have a variety of commercial applications including urban pest control, agricultural use to increase crop yields, and prevention of proliferation of insect-borne diseases. Many pesticides in current use are synthetic molecules such as organochlorine and organophosphate compounds. Some synthetic insecticides suffer drawbacks including high production costs, concern over environmental sustainability, harmful effects on human health, targeting non-intended insect species, and the evolution of resistance among insect populations. Thus, there is a large worldwide need and demand for environmentally safe and effective insecticides. Here we show that Erythritol, a non-nutritive sugar alcohol, was toxic to the fruit fly Drosophila melanogaster. Ingested erythritol decreased fruit fly longevity in a dose-dependent manner, and erythritol was ingested by flies that had free access to control (sucrose) foods in choice and CAFE studies. Erythritol was US FDA approved in 2001 and is used as a food additive in the United States. Our results demonstrate, for the first time, that erythritol may be used as a novel, environmentally sustainable and human safe approach for insect pest control.Kaitlin M BaudierSimon D Kaschock-MarendaNirali PatelKatherine L DiangelusSean O'DonnellDaniel R MarendaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98949 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaitlin M Baudier Simon D Kaschock-Marenda Nirali Patel Katherine L Diangelus Sean O'Donnell Daniel R Marenda Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
description	Insecticides have a variety of commercial applications including urban pest control, agricultural use to increase crop yields, and prevention of proliferation of insect-borne diseases. Many pesticides in current use are synthetic molecules such as organochlorine and organophosphate compounds. Some synthetic insecticides suffer drawbacks including high production costs, concern over environmental sustainability, harmful effects on human health, targeting non-intended insect species, and the evolution of resistance among insect populations. Thus, there is a large worldwide need and demand for environmentally safe and effective insecticides. Here we show that Erythritol, a non-nutritive sugar alcohol, was toxic to the fruit fly Drosophila melanogaster. Ingested erythritol decreased fruit fly longevity in a dose-dependent manner, and erythritol was ingested by flies that had free access to control (sucrose) foods in choice and CAFE studies. Erythritol was US FDA approved in 2001 and is used as a food additive in the United States. Our results demonstrate, for the first time, that erythritol may be used as a novel, environmentally sustainable and human safe approach for insect pest control.
format	article
author	Kaitlin M Baudier Simon D Kaschock-Marenda Nirali Patel Katherine L Diangelus Sean O'Donnell Daniel R Marenda
author_facet	Kaitlin M Baudier Simon D Kaschock-Marenda Nirali Patel Katherine L Diangelus Sean O'Donnell Daniel R Marenda
author_sort	Kaitlin M Baudier
title	Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
title_short	Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
title_full	Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
title_fullStr	Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
title_full_unstemmed	Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
title_sort	erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/c9e9109f40694d258d508be20e1e683b
work_keys_str_mv	AT kaitlinmbaudier erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide AT simondkaschockmarenda erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide AT niralipatel erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide AT katherineldiangelus erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide AT seanodonnell erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide AT danielrmarenda erythritolanonnutritivesugaralcoholsweetenerandthemaincomponentoftruviaisapalatableingestedinsecticide
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Erythritol, a non-nutritive sugar alcohol sweetener and the main component of truvia®, is a palatable ingested insecticide.

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