Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development

Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely...

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Autores principales:	Estelle Rascol, Sandrine Villette, Etienne Harté, Isabel D. Alves
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	plasmon waveguide resonance lipid membrane G-protein-coupled receptor lipid–peptide interaction membrane active peptide molecular imprinted polymer Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/c9eaafad21f84deab018de4333eb473c
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spelling	oai:doaj.org-article:c9eaafad21f84deab018de4333eb473c2021-11-11T18:27:23ZPlasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development10.3390/molecules262164421420-3049https://doaj.org/article/c9eaafad21f84deab018de4333eb473c2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6442https://doaj.org/toc/1420-3049Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely, the ability to monitor both mass and structural changes. PWR allows anisotropy information to be obtained and is ideal for the investigation of molecular interactions occurring in anisotropic-oriented thin films. In this review, we will revisit main PWR applications, aiming at characterizing molecular interactions occurring (1) at lipid membranes deposited in the sensor and (2) in chemically modified sensors. Among the most widely used applications is the investigation of G-protein coupled receptor (GPCR) ligand activation and the study of the lipid environment’s impact on this process. Pioneering PWR studies on GPCRs were carried out thanks to the strong and effective collaboration between two laboratories in the University of Arizona leaded by Dr. Gordon Tollin and Dr. Victor J. Hruby. This review provides an overview of the main applications of PWR and provides a historical perspective on the development of instruments since the first prototype and continuous technological improvements to ongoing and future developments, aiming at broadening the information obtained and expanding the application portfolio.Estelle RascolSandrine VilletteEtienne HartéIsabel D. AlvesMDPI AGarticleplasmon waveguide resonancelipid membraneG-protein-coupled receptorlipid–peptide interactionmembrane active peptidemolecular imprinted polymerOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6442, p 6442 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plasmon waveguide resonance lipid membrane G-protein-coupled receptor lipid–peptide interaction membrane active peptide molecular imprinted polymer Organic chemistry QD241-441
spellingShingle	plasmon waveguide resonance lipid membrane G-protein-coupled receptor lipid–peptide interaction membrane active peptide molecular imprinted polymer Organic chemistry QD241-441 Estelle Rascol Sandrine Villette Etienne Harté Isabel D. Alves Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
description	Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely, the ability to monitor both mass and structural changes. PWR allows anisotropy information to be obtained and is ideal for the investigation of molecular interactions occurring in anisotropic-oriented thin films. In this review, we will revisit main PWR applications, aiming at characterizing molecular interactions occurring (1) at lipid membranes deposited in the sensor and (2) in chemically modified sensors. Among the most widely used applications is the investigation of G-protein coupled receptor (GPCR) ligand activation and the study of the lipid environment’s impact on this process. Pioneering PWR studies on GPCRs were carried out thanks to the strong and effective collaboration between two laboratories in the University of Arizona leaded by Dr. Gordon Tollin and Dr. Victor J. Hruby. This review provides an overview of the main applications of PWR and provides a historical perspective on the development of instruments since the first prototype and continuous technological improvements to ongoing and future developments, aiming at broadening the information obtained and expanding the application portfolio.
format	article
author	Estelle Rascol Sandrine Villette Etienne Harté Isabel D. Alves
author_facet	Estelle Rascol Sandrine Villette Etienne Harté Isabel D. Alves
author_sort	Estelle Rascol
title	Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
title_short	Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
title_full	Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
title_fullStr	Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
title_full_unstemmed	Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development
title_sort	plasmon waveguide resonance: principles, applications and historical perspectives on instrument development
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c9eaafad21f84deab018de4333eb473c
work_keys_str_mv	AT estellerascol plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT sandrinevillette plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT etienneharte plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment AT isabeldalves plasmonwaveguideresonanceprinciplesapplicationsandhistoricalperspectivesoninstrumentdevelopment
_version_	1718431850125328384

Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development

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