Association study of MIF promoter polymorphisms with suicide completers in the Japanese population
Naofumi Shimmyo,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Satoshi Okazaki,1 Shuken Boku,1 Kentaro Mouri,1 Tadasu Horai,1 Motonori Takahashi,2 Yasuhiro Ueno,2 Osamu Shirakawa,3 Ichiro Sora1 1Department of Psychiatry, 2Division of Legal Medicine, Department of Community Medicine and Social Health Science,...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/c9eb4c877d824ae08518bebbc45d2ad1 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:c9eb4c877d824ae08518bebbc45d2ad1 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:c9eb4c877d824ae08518bebbc45d2ad12021-12-02T01:31:16ZAssociation study of MIF promoter polymorphisms with suicide completers in the Japanese population1178-2021https://doaj.org/article/c9eb4c877d824ae08518bebbc45d2ad12017-03-01T00:00:00Zhttps://www.dovepress.com/association-study-of-mif-promoter-polymorphisms-with-suicide-completer-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Naofumi Shimmyo,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Satoshi Okazaki,1 Shuken Boku,1 Kentaro Mouri,1 Tadasu Horai,1 Motonori Takahashi,2 Yasuhiro Ueno,2 Osamu Shirakawa,3 Ichiro Sora1 1Department of Psychiatry, 2Division of Legal Medicine, Department of Community Medicine and Social Health Science, Kobe University Graduate School of Medicine, Kobe, 3Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, Japan Background: Numerous studies suggest that inflammation plays a key role in suicidal behavior. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has received increasing attention in depression research. However, no study has investigated whether MIF has genetic involvement in completed suicide. In this study, we sought to explore the relationship between two functional polymorphisms on the MIF gene promoter (MIF-794CATT5–8 microsatellite and MIF-173G/C single-nucleotide polymorphism [SNP]) and completed suicide by using one of the largest samples of suicide completers ever reported.Methods: The subjects comprised 602 suicide completers and 728 healthy controls. We genotyped MIF-794CATT5–8 microsatellite by polymerase chain reaction–based size discrimination assay and MIF-173G/C SNP by TaqMan® SNP genotyping assay. The allele-, genotype-, or haplotype-based association analyses between the suicide completers and the controls were carried out with the χ2 test, the Cochran–Armitage trend test, or Fisher’s exact test.Results: Analyses of allele or genotype frequency distributions of the polymorphisms studied here did not reveal any significant differences between the suicide completers and the controls. Haplotype analysis also revealed no association with completed suicide.Conclusion: To our knowledge, this is the first study that has examined the genetic association between MIF and completed suicide. Our results suggest that the effects of MIF-794CATT5–8 microsatellite and MIF-173G/C SNP on the MIF gene promoter might not contribute to the genetic risk of completed suicide in the Japanese population. Keywords: MIF, suicide, microsatellite, SNP, haplotype, promoter regionShimmyo NHishimoto AOtsuka IOkazaki SBoku SMouri KHorai TTakahashi MUeno YShirakawa OSora IDove Medical PressarticleMIFsuicidemicrosatelliteSNPNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 899-908 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
MIF suicide microsatellite SNP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
MIF suicide microsatellite SNP Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shimmyo N Hishimoto A Otsuka I Okazaki S Boku S Mouri K Horai T Takahashi M Ueno Y Shirakawa O Sora I Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| description |
Naofumi Shimmyo,1 Akitoyo Hishimoto,1 Ikuo Otsuka,1 Satoshi Okazaki,1 Shuken Boku,1 Kentaro Mouri,1 Tadasu Horai,1 Motonori Takahashi,2 Yasuhiro Ueno,2 Osamu Shirakawa,3 Ichiro Sora1 1Department of Psychiatry, 2Division of Legal Medicine, Department of Community Medicine and Social Health Science, Kobe University Graduate School of Medicine, Kobe, 3Department of Neuropsychiatry, Kindai University Faculty of Medicine, Osaka, Japan Background: Numerous studies suggest that inflammation plays a key role in suicidal behavior. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has received increasing attention in depression research. However, no study has investigated whether MIF has genetic involvement in completed suicide. In this study, we sought to explore the relationship between two functional polymorphisms on the MIF gene promoter (MIF-794CATT5–8 microsatellite and MIF-173G/C single-nucleotide polymorphism [SNP]) and completed suicide by using one of the largest samples of suicide completers ever reported.Methods: The subjects comprised 602 suicide completers and 728 healthy controls. We genotyped MIF-794CATT5–8 microsatellite by polymerase chain reaction–based size discrimination assay and MIF-173G/C SNP by TaqMan® SNP genotyping assay. The allele-, genotype-, or haplotype-based association analyses between the suicide completers and the controls were carried out with the χ2 test, the Cochran–Armitage trend test, or Fisher’s exact test.Results: Analyses of allele or genotype frequency distributions of the polymorphisms studied here did not reveal any significant differences between the suicide completers and the controls. Haplotype analysis also revealed no association with completed suicide.Conclusion: To our knowledge, this is the first study that has examined the genetic association between MIF and completed suicide. Our results suggest that the effects of MIF-794CATT5–8 microsatellite and MIF-173G/C SNP on the MIF gene promoter might not contribute to the genetic risk of completed suicide in the Japanese population. Keywords: MIF, suicide, microsatellite, SNP, haplotype, promoter region |
| format |
article |
| author |
Shimmyo N Hishimoto A Otsuka I Okazaki S Boku S Mouri K Horai T Takahashi M Ueno Y Shirakawa O Sora I |
| author_facet |
Shimmyo N Hishimoto A Otsuka I Okazaki S Boku S Mouri K Horai T Takahashi M Ueno Y Shirakawa O Sora I |
| author_sort |
Shimmyo N |
| title |
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| title_short |
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| title_full |
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| title_fullStr |
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| title_full_unstemmed |
Association study of MIF promoter polymorphisms with suicide completers in the Japanese population |
| title_sort |
association study of mif promoter polymorphisms with suicide completers in the japanese population |
| publisher |
Dove Medical Press |
| publishDate |
2017 |
| url |
https://doaj.org/article/c9eb4c877d824ae08518bebbc45d2ad1 |
| work_keys_str_mv |
AT shimmyon associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT hishimotoa associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT otsukai associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT okazakis associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT bokus associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT mourik associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT horait associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT takahashim associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT uenoy associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT shirakawao associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation AT sorai associationstudyofmifpromoterpolymorphismswithsuicidecompletersinthejapanesepopulation |
| _version_ |
1718403039774113792 |