Toxin secretion and trafficking by Mycobacterium tuberculosis

The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al. show that the ESX-4 system is required for TNT secretion and that ESX-2 and ESX-4 systems work in concert with ESX-1 to permeabilize...

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Autores principales:	David Pajuelo, Uday Tak, Lei Zhang, Olga Danilchanka, Anna D. Tischler, Michael Niederweis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9ec7194658a4792a80fd186b7ed107b
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spelling	oai:doaj.org-article:c9ec7194658a4792a80fd186b7ed107b2021-11-21T12:36:06ZToxin secretion and trafficking by Mycobacterium tuberculosis10.1038/s41467-021-26925-12041-1723https://doaj.org/article/c9ec7194658a4792a80fd186b7ed107b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26925-1https://doaj.org/toc/2041-1723The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al. show that the ESX-4 system is required for TNT secretion and that ESX-2 and ESX-4 systems work in concert with ESX-1 to permeabilize the phagosomal membrane and enable trafficking of TNT into the cytoplasm of macrophages infected with Mtb.David PajueloUday TakLei ZhangOlga DanilchankaAnna D. TischlerMichael NiederweisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Pajuelo Uday Tak Lei Zhang Olga Danilchanka Anna D. Tischler Michael Niederweis Toxin secretion and trafficking by Mycobacterium tuberculosis
description	The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al. show that the ESX-4 system is required for TNT secretion and that ESX-2 and ESX-4 systems work in concert with ESX-1 to permeabilize the phagosomal membrane and enable trafficking of TNT into the cytoplasm of macrophages infected with Mtb.
format	article
author	David Pajuelo Uday Tak Lei Zhang Olga Danilchanka Anna D. Tischler Michael Niederweis
author_facet	David Pajuelo Uday Tak Lei Zhang Olga Danilchanka Anna D. Tischler Michael Niederweis
author_sort	David Pajuelo
title	Toxin secretion and trafficking by Mycobacterium tuberculosis
title_short	Toxin secretion and trafficking by Mycobacterium tuberculosis
title_full	Toxin secretion and trafficking by Mycobacterium tuberculosis
title_fullStr	Toxin secretion and trafficking by Mycobacterium tuberculosis
title_full_unstemmed	Toxin secretion and trafficking by Mycobacterium tuberculosis
title_sort	toxin secretion and trafficking by mycobacterium tuberculosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9ec7194658a4792a80fd186b7ed107b
work_keys_str_mv	AT davidpajuelo toxinsecretionandtraffickingbymycobacteriumtuberculosis AT udaytak toxinsecretionandtraffickingbymycobacteriumtuberculosis AT leizhang toxinsecretionandtraffickingbymycobacteriumtuberculosis AT olgadanilchanka toxinsecretionandtraffickingbymycobacteriumtuberculosis AT annadtischler toxinsecretionandtraffickingbymycobacteriumtuberculosis AT michaelniederweis toxinsecretionandtraffickingbymycobacteriumtuberculosis
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Toxin secretion and trafficking by Mycobacterium tuberculosis

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