Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of KoreaBackground: Sarcopenia is associa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Baeg MK, Choi MG, Ko SH, Lim CH, Kim JS, Cho YK, Park JM, Cho YS, Lee BI, Lee IS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Sarcopenia Helicobacter pylori Eradication Bioelectrical impedance analysis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/c9edb032b76540cf8ca81598aa47861d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9edb032b76540cf8ca81598aa47861d
record_format	dspace
spelling	oai:doaj.org-article:c9edb032b76540cf8ca81598aa47861d2021-12-02T04:41:51ZElderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass1178-1998https://doaj.org/article/c9edb032b76540cf8ca81598aa47861d2015-10-01T00:00:00Zhttps://www.dovepress.com/elderly-women-who-received-helicobacter-pylori-eradicating-therapy-hav-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of KoreaBackground: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP) eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM), which is an integral component of sarcopenia.Materials and methods: Healthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002). Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013) was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051) had a preventive tendency.Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.Keywords: sarcopenia, Helicobacter pylori, eradication, bioelectrical impedance analysisBaeg MKChoi MGKo SHLim CHKim JSCho YKPark JMCho YSLee BILee ISDove Medical PressarticleSarcopeniaHelicobacter pyloriEradicationBioelectrical impedance analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 1771-1777 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sarcopenia Helicobacter pylori Eradication Bioelectrical impedance analysis Geriatrics RC952-954.6
spellingShingle	Sarcopenia Helicobacter pylori Eradication Bioelectrical impedance analysis Geriatrics RC952-954.6 Baeg MK Choi MG Ko SH Lim CH Kim JS Cho YK Park JM Cho YS Lee BI Lee IS Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
description	Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of KoreaBackground: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP) eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM), which is an integral component of sarcopenia.Materials and methods: Healthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002). Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013) was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051) had a preventive tendency.Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.Keywords: sarcopenia, Helicobacter pylori, eradication, bioelectrical impedance analysis
format	article
author	Baeg MK Choi MG Ko SH Lim CH Kim JS Cho YK Park JM Cho YS Lee BI Lee IS
author_facet	Baeg MK Choi MG Ko SH Lim CH Kim JS Cho YK Park JM Cho YS Lee BI Lee IS
author_sort	Baeg MK
title	Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
title_short	Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
title_full	Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
title_fullStr	Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
title_full_unstemmed	Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
title_sort	elderly women who received helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/c9edb032b76540cf8ca81598aa47861d
work_keys_str_mv	AT baegmk elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT choimg elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT kosh elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT limch elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT kimjs elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT choyk elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT parkjm elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT choys elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT leebi elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass AT leeis elderlywomenwhoreceivedhelicobacterpylorieradicatingtherapyhavereducedriskoflowskeletalmusclemass
_version_	1718401150439391232

Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

Ejemplares similares