Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7

The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in breast cancer.

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Autores principales: Zhengkui Zhang, Yao Fan, Feng Xie, Hang Zhou, Ke Jin, Li Shao, Wenhao Shi, Pengfei Fang, Bing Yang, Hans van Dam, Peter ten Dijke, Xiaofeng Zheng, Xiaohua Yan, Junling Jia, Min Zheng, Jin Jin, Chen Ding, Sheng Ye, Fangfang Zhou, Long Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/c9f4c20d0b034062b275d5bddb7b2a17
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spelling oai:doaj.org-article:c9f4c20d0b034062b275d5bddb7b2a172021-12-02T14:41:20ZBreast cancer metastasis suppressor OTUD1 deubiquitinates SMAD710.1038/s41467-017-02029-72041-1723https://doaj.org/article/c9f4c20d0b034062b275d5bddb7b2a172017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02029-7https://doaj.org/toc/2041-1723The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in breast cancer.Zhengkui ZhangYao FanFeng XieHang ZhouKe JinLi ShaoWenhao ShiPengfei FangBing YangHans van DamPeter ten DijkeXiaofeng ZhengXiaohua YanJunling JiaMin ZhengJin JinChen DingSheng YeFangfang ZhouLong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhengkui Zhang
Yao Fan
Feng Xie
Hang Zhou
Ke Jin
Li Shao
Wenhao Shi
Pengfei Fang
Bing Yang
Hans van Dam
Peter ten Dijke
Xiaofeng Zheng
Xiaohua Yan
Junling Jia
Min Zheng
Jin Jin
Chen Ding
Sheng Ye
Fangfang Zhou
Long Zhang
Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
description The activation of TGF-β signaling has been implicated in cancer metastasis. Here, the authors show that OTUD1 suppresses metastasis by antagonizing the TGF-β pathway via the deubiquitination of SMAD7, and its loss correlates with poor prognosis in breast cancer.
format article
author Zhengkui Zhang
Yao Fan
Feng Xie
Hang Zhou
Ke Jin
Li Shao
Wenhao Shi
Pengfei Fang
Bing Yang
Hans van Dam
Peter ten Dijke
Xiaofeng Zheng
Xiaohua Yan
Junling Jia
Min Zheng
Jin Jin
Chen Ding
Sheng Ye
Fangfang Zhou
Long Zhang
author_facet Zhengkui Zhang
Yao Fan
Feng Xie
Hang Zhou
Ke Jin
Li Shao
Wenhao Shi
Pengfei Fang
Bing Yang
Hans van Dam
Peter ten Dijke
Xiaofeng Zheng
Xiaohua Yan
Junling Jia
Min Zheng
Jin Jin
Chen Ding
Sheng Ye
Fangfang Zhou
Long Zhang
author_sort Zhengkui Zhang
title Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
title_short Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
title_full Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
title_fullStr Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
title_full_unstemmed Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
title_sort breast cancer metastasis suppressor otud1 deubiquitinates smad7
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c9f4c20d0b034062b275d5bddb7b2a17
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