Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9...

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Autores principales:	David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c9f52c1c744446f184d2f16004401292
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spelling	oai:doaj.org-article:c9f52c1c744446f184d2f160044012922021-12-02T14:39:42ZLoss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer10.1038/s41467-019-08586-32041-1723https://doaj.org/article/c9f52c1c744446f184d2f160044012922019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08586-3https://doaj.org/toc/2041-1723Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.David M. GayRachel A. RidgwayMiryam MüllerMichael C. HodderAnn HedleyWilliam ClarkJoshua D. LeachRene JackstadtColin NixonDavid J. HuelsAndrew D. CampbellThomas G. BirdOwen J. SansomNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
description	Whether the Wnt enhanceosome’ components BCL9/9l can affect intestinal homeostasis and tumorigenesis is still unclear. Using conditional Bcl9/9l KO mice, the authors of this study show that the BCL9/9l complex is required for intestinal stem cells to drive tissue regeneration and that loss of BCL9/9l suppresses Wnt-driven transformation.
format	article
author	David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom
author_facet	David M. Gay Rachel A. Ridgway Miryam Müller Michael C. Hodder Ann Hedley William Clark Joshua D. Leach Rene Jackstadt Colin Nixon David J. Huels Andrew D. Campbell Thomas G. Bird Owen J. Sansom
author_sort	David M. Gay
title	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_short	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_full	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_fullStr	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_full_unstemmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
title_sort	loss of bcl9/9l suppresses wnt driven tumourigenesis in models that recapitulate human cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c9f52c1c744446f184d2f16004401292
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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

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