Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

ObjectivePreviously, we found that the presence of maternal serum metals before the 24th week of gestation prospectively increased fasting plasma glucose (FPG) at 24–28 weeks. We further explored the prospective association between levels of metals and neonatal outcomes and assessed the mediating ef...

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Autores principales:	Zixing Zhou, Dandan Yu, Gengdong Chen, Pengsheng Li, Lijuan Wang, Jie Yang, Jiaming Rao, Dongxin Lin, Dazhi Fan, Haiyan Wang, Xiaoyan Gou, Xiaoling Guo, Dongmei Suo, Fang Huang, Zhengping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metal fasting plasma glucose birth outcome mediating effect cohort study Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/c9f6308dcb61496cae84e5c0bf8dcacd
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spelling	oai:doaj.org-article:c9f6308dcb61496cae84e5c0bf8dcacd2021-11-16T06:43:42ZFasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study1664-239210.3389/fendo.2021.763693https://doaj.org/article/c9f6308dcb61496cae84e5c0bf8dcacd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.763693/fullhttps://doaj.org/toc/1664-2392ObjectivePreviously, we found that the presence of maternal serum metals before the 24th week of gestation prospectively increased fasting plasma glucose (FPG) at 24–28 weeks. We further explored the prospective association between levels of metals and neonatal outcomes and assessed the mediating effects of FPG on these relationships.MethodsA total of 7,644 pregnant women were included in a retrospective cohort study, and the relationships between metals [manganese (Mn), copper (Cu), lead (Pb), zinc (Zn), and magnesium (Mg)] and birth outcomes were explored. Quantile and linear regressions were performed to detect the shifts and associations between metals and neonatal size distribution focused on the 10th, 50th, and 90th percentiles. Mediation analysis was performed to assess the mediating effect of FPG on metals and birth outcomes.ResultsAfter adjustment, a 50% increase in Mn and Zn levels was related to a 0.136-cm (95% CI: 0.067–0.205) and 0.120-cm (95% CI: 0.046–0.193) increase in head circumference, respectively. Based on head circumference distribution, the magnitude of the association with Mn was smaller at the upper tail, while the magnitude of correlation with Zn was greater at the upper tail. A 50% increase in Mn and Zn levels was related to a 0.135-cm (95% CI: 0.058–0.212) and 0.095-cm (95% CI: 0.013–0.178) increase in chest circumference, respectively. The magnitude of the association with Mn increased with increasing chest circumference, while the magnitude of correlation with Zn decreased with increasing chest circumference. FPG explained 10.00% and 17.65% of the associations of Mn with head and chest circumference. A positive indirect effect of Zn associated with head circumference (0.004, 95% CI: 0.002–0.006) and chest circumference (0.005, 95% CI: 0.003–0.008) through FPG was also observed, and the estimated proportion of the mediating effect was 13.79% and 26.32%, respectively.ConclusionMaternal serum Mn and Zn levels before the 24th week of gestation may prospectively increase the circumference of the neonatal head and chest. FPG at 24–28 weeks had positive mediating effects on these relationships. Further research is needed to identify a balance between maternal blood glucose and birth size.Zixing ZhouZixing ZhouDandan YuGengdong ChenGengdong ChenPengsheng LiPengsheng LiLijuan WangJie YangJiaming RaoJiaming RaoDongxin LinDongxin LinDazhi FanDazhi FanHaiyan WangHaiyan WangXiaoyan GouXiaoyan GouXiaoling GuoXiaoling GuoDongmei SuoFang HuangZhengping LiuZhengping LiuFrontiers Media S.A.articlemetalfasting plasma glucosebirth outcomemediating effectcohort studyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metal fasting plasma glucose birth outcome mediating effect cohort study Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	metal fasting plasma glucose birth outcome mediating effect cohort study Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zixing Zhou Zixing Zhou Dandan Yu Gengdong Chen Gengdong Chen Pengsheng Li Pengsheng Li Lijuan Wang Jie Yang Jiaming Rao Jiaming Rao Dongxin Lin Dongxin Lin Dazhi Fan Dazhi Fan Haiyan Wang Haiyan Wang Xiaoyan Gou Xiaoyan Gou Xiaoling Guo Xiaoling Guo Dongmei Suo Fang Huang Zhengping Liu Zhengping Liu Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
description	ObjectivePreviously, we found that the presence of maternal serum metals before the 24th week of gestation prospectively increased fasting plasma glucose (FPG) at 24–28 weeks. We further explored the prospective association between levels of metals and neonatal outcomes and assessed the mediating effects of FPG on these relationships.MethodsA total of 7,644 pregnant women were included in a retrospective cohort study, and the relationships between metals [manganese (Mn), copper (Cu), lead (Pb), zinc (Zn), and magnesium (Mg)] and birth outcomes were explored. Quantile and linear regressions were performed to detect the shifts and associations between metals and neonatal size distribution focused on the 10th, 50th, and 90th percentiles. Mediation analysis was performed to assess the mediating effect of FPG on metals and birth outcomes.ResultsAfter adjustment, a 50% increase in Mn and Zn levels was related to a 0.136-cm (95% CI: 0.067–0.205) and 0.120-cm (95% CI: 0.046–0.193) increase in head circumference, respectively. Based on head circumference distribution, the magnitude of the association with Mn was smaller at the upper tail, while the magnitude of correlation with Zn was greater at the upper tail. A 50% increase in Mn and Zn levels was related to a 0.135-cm (95% CI: 0.058–0.212) and 0.095-cm (95% CI: 0.013–0.178) increase in chest circumference, respectively. The magnitude of the association with Mn increased with increasing chest circumference, while the magnitude of correlation with Zn decreased with increasing chest circumference. FPG explained 10.00% and 17.65% of the associations of Mn with head and chest circumference. A positive indirect effect of Zn associated with head circumference (0.004, 95% CI: 0.002–0.006) and chest circumference (0.005, 95% CI: 0.003–0.008) through FPG was also observed, and the estimated proportion of the mediating effect was 13.79% and 26.32%, respectively.ConclusionMaternal serum Mn and Zn levels before the 24th week of gestation may prospectively increase the circumference of the neonatal head and chest. FPG at 24–28 weeks had positive mediating effects on these relationships. Further research is needed to identify a balance between maternal blood glucose and birth size.
format	article
author	Zixing Zhou Zixing Zhou Dandan Yu Gengdong Chen Gengdong Chen Pengsheng Li Pengsheng Li Lijuan Wang Jie Yang Jiaming Rao Jiaming Rao Dongxin Lin Dongxin Lin Dazhi Fan Dazhi Fan Haiyan Wang Haiyan Wang Xiaoyan Gou Xiaoyan Gou Xiaoling Guo Xiaoling Guo Dongmei Suo Fang Huang Zhengping Liu Zhengping Liu
author_facet	Zixing Zhou Zixing Zhou Dandan Yu Gengdong Chen Gengdong Chen Pengsheng Li Pengsheng Li Lijuan Wang Jie Yang Jiaming Rao Jiaming Rao Dongxin Lin Dongxin Lin Dazhi Fan Dazhi Fan Haiyan Wang Haiyan Wang Xiaoyan Gou Xiaoyan Gou Xiaoling Guo Xiaoling Guo Dongmei Suo Fang Huang Zhengping Liu Zhengping Liu
author_sort	Zixing Zhou
title	Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
title_short	Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
title_full	Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
title_fullStr	Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
title_full_unstemmed	Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study
title_sort	fasting plasma glucose mediates the prospective effect of maternal metal level on birth outcomes: a retrospective and longitudinal population-based cohort study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c9f6308dcb61496cae84e5c0bf8dcacd
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Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

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