Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens

Abstract Wooden breast (WB) and white striping (WS) are highly prevalent and economically damaging muscle disorders of modern commercial broiler chickens characterized respectively by palpable firmness and fatty white striations running parallel to the muscle fiber. High feed efficiency and rapid gr...

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Autores principales:	Juniper A. Lake, Jack C. M. Dekkers, Behnam Abasht
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9f8129d87204e54ba06e6b8b40261ff
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spelling	oai:doaj.org-article:c9f8129d87204e54ba06e6b8b40261ff2021-12-02T11:45:04ZGenetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens10.1038/s41598-021-86176-42045-2322https://doaj.org/article/c9f8129d87204e54ba06e6b8b40261ff2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86176-4https://doaj.org/toc/2045-2322Abstract Wooden breast (WB) and white striping (WS) are highly prevalent and economically damaging muscle disorders of modern commercial broiler chickens characterized respectively by palpable firmness and fatty white striations running parallel to the muscle fiber. High feed efficiency and rapid growth, especially of the breast muscle, are believed to contribute to development of such muscle defects; however, their etiology remains poorly understood. To gain insight into the genetic basis of these myopathies, a genome-wide association study was conducted using a commercial crossbred broiler population (n = 1193). Heritability was estimated at 0.5 for WB and WS with high genetic correlation between them (0.88). GWAS revealed 28 quantitative trait loci (QTL) on five chromosomes for WB and 6 QTL on one chromosome for WS, with the majority of QTL for both myopathies located in a ~ 8 Mb region of chromosome 5. This region has highly conserved synteny with a portion of human chromosome 11 containing a cluster of imprinted genes associated with growth and metabolic disorders such as type 2 diabetes and Beckwith-Wiedemann syndrome. Candidate genes include potassium voltage-gated channel subfamily Q member 1 (KCNQ1), involved in insulin secretion and cardiac electrical activity, lymphocyte-specific protein 1 (LSP1), involved in inflammation and immune response.Juniper A. LakeJack C. M. DekkersBehnam AbashtNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juniper A. Lake Jack C. M. Dekkers Behnam Abasht Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
description	Abstract Wooden breast (WB) and white striping (WS) are highly prevalent and economically damaging muscle disorders of modern commercial broiler chickens characterized respectively by palpable firmness and fatty white striations running parallel to the muscle fiber. High feed efficiency and rapid growth, especially of the breast muscle, are believed to contribute to development of such muscle defects; however, their etiology remains poorly understood. To gain insight into the genetic basis of these myopathies, a genome-wide association study was conducted using a commercial crossbred broiler population (n = 1193). Heritability was estimated at 0.5 for WB and WS with high genetic correlation between them (0.88). GWAS revealed 28 quantitative trait loci (QTL) on five chromosomes for WB and 6 QTL on one chromosome for WS, with the majority of QTL for both myopathies located in a ~ 8 Mb region of chromosome 5. This region has highly conserved synteny with a portion of human chromosome 11 containing a cluster of imprinted genes associated with growth and metabolic disorders such as type 2 diabetes and Beckwith-Wiedemann syndrome. Candidate genes include potassium voltage-gated channel subfamily Q member 1 (KCNQ1), involved in insulin secretion and cardiac electrical activity, lymphocyte-specific protein 1 (LSP1), involved in inflammation and immune response.
format	article
author	Juniper A. Lake Jack C. M. Dekkers Behnam Abasht
author_facet	Juniper A. Lake Jack C. M. Dekkers Behnam Abasht
author_sort	Juniper A. Lake
title	Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
title_short	Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
title_full	Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
title_fullStr	Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
title_full_unstemmed	Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
title_sort	genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c9f8129d87204e54ba06e6b8b40261ff
work_keys_str_mv	AT juniperalake geneticbasisandidentificationofcandidategenesforwoodenbreastandwhitestripingincommercialbroilerchickens AT jackcmdekkers geneticbasisandidentificationofcandidategenesforwoodenbreastandwhitestripingincommercialbroilerchickens AT behnamabasht geneticbasisandidentificationofcandidategenesforwoodenbreastandwhitestripingincommercialbroilerchickens
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Genetic basis and identification of candidate genes for wooden breast and white striping in commercial broiler chickens

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