Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.

Gene-environment interactions contribute to the risk for Autism Spectrum Disorder (ASD). Among environmental factors, prenatal exposure to stress may increase the risk for ASD. To examine if there is an interaction between exposure to maternal stress and reduced dosage or loss of Shank3, wild-type (...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bibiana K Y Wong, Jaclyn B Murry, Rajesh Ramakrishnan, Fang He, Alfred Balasa, Gary R Stinnett, Steen E Pedersen, Robia G Pautler, Ignatia B Van den Veyver
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c9f844e4a110406e8057fcb7eafb711d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c9f844e4a110406e8057fcb7eafb711d
record_format	dspace
spelling	oai:doaj.org-article:c9f844e4a110406e8057fcb7eafb711d2021-12-02T20:11:30ZMaternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.1932-620310.1371/journal.pone.0224876https://doaj.org/article/c9f844e4a110406e8057fcb7eafb711d2019-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0224876https://doaj.org/toc/1932-6203Gene-environment interactions contribute to the risk for Autism Spectrum Disorder (ASD). Among environmental factors, prenatal exposure to stress may increase the risk for ASD. To examine if there is an interaction between exposure to maternal stress and reduced dosage or loss of Shank3, wild-type (WT), heterozygous (HET) and homozygous (HOM) female mice carrying a deletion of exons four through nine of Shank3 (Shank3ex4-9) were exposed to chronic unpredictable mild stress (CUMS) from prior to conception throughout gestation. This study examined maternal care of these dams and the white matter microstructure in the brains of their adult male offspring. Overall, our findings suggest that maternal exposure to CUMS increased pup-directed care for dams of all three genotypes. Compared to WT and HET dams, HOM dams also exhibited increased maternal care behaviors with increased time spent in the nest and reduced cage exploration, regardless of exposure to CUMS. Diffusion tensor imaging showed higher mean fractional anisotropy in the hippocampal stratum radiatum of WT and HOM male offspring from dams exposed to CUMS and HOM offspring from unexposed dams, compared to WT male offspring from unexposed dams. These data support that CUMS in Shank3-mutant dams results in subtle maternal care alterations and long-lasting changes in the white matter of the hippocampus of their offspring.Bibiana K Y WongJaclyn B MurryRajesh RamakrishnanFang HeAlfred BalasaGary R StinnettSteen E PedersenRobia G PautlerIgnatia B Van den VeyverPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 14, Iss 11, p e0224876 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bibiana K Y Wong Jaclyn B Murry Rajesh Ramakrishnan Fang He Alfred Balasa Gary R Stinnett Steen E Pedersen Robia G Pautler Ignatia B Van den Veyver Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
description	Gene-environment interactions contribute to the risk for Autism Spectrum Disorder (ASD). Among environmental factors, prenatal exposure to stress may increase the risk for ASD. To examine if there is an interaction between exposure to maternal stress and reduced dosage or loss of Shank3, wild-type (WT), heterozygous (HET) and homozygous (HOM) female mice carrying a deletion of exons four through nine of Shank3 (Shank3ex4-9) were exposed to chronic unpredictable mild stress (CUMS) from prior to conception throughout gestation. This study examined maternal care of these dams and the white matter microstructure in the brains of their adult male offspring. Overall, our findings suggest that maternal exposure to CUMS increased pup-directed care for dams of all three genotypes. Compared to WT and HET dams, HOM dams also exhibited increased maternal care behaviors with increased time spent in the nest and reduced cage exploration, regardless of exposure to CUMS. Diffusion tensor imaging showed higher mean fractional anisotropy in the hippocampal stratum radiatum of WT and HOM male offspring from dams exposed to CUMS and HOM offspring from unexposed dams, compared to WT male offspring from unexposed dams. These data support that CUMS in Shank3-mutant dams results in subtle maternal care alterations and long-lasting changes in the white matter of the hippocampus of their offspring.
format	article
author	Bibiana K Y Wong Jaclyn B Murry Rajesh Ramakrishnan Fang He Alfred Balasa Gary R Stinnett Steen E Pedersen Robia G Pautler Ignatia B Van den Veyver
author_facet	Bibiana K Y Wong Jaclyn B Murry Rajesh Ramakrishnan Fang He Alfred Balasa Gary R Stinnett Steen E Pedersen Robia G Pautler Ignatia B Van den Veyver
author_sort	Bibiana K Y Wong
title	Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
title_short	Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
title_full	Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
title_fullStr	Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
title_full_unstemmed	Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
title_sort	maternal stress in shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.
publisher	Public Library of Science (PLoS)
publishDate	2019
url	https://doaj.org/article/c9f844e4a110406e8057fcb7eafb711d
work_keys_str_mv	AT bibianakywong maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT jaclynbmurry maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT rajeshramakrishnan maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT fanghe maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT alfredbalasa maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT garyrstinnett maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT steenepedersen maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT robiagpautler maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring AT ignatiabvandenveyver maternalstressinshank3ex49miceincreasespupdirectedcareandaltersbrainwhitematterinmaleoffspring
_version_	1718374909265051648

Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring.

Ejemplares similares