Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes

Summary: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy linked to diverse cognitive abnormalities. The electroencephalogram of patients shows focal interictal epileptic spikes, particularly during non-rapid eye movement (NonREM) sleep. Spike formation invol...

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Autores principales:	Jens G. Klinzing, Lilian Tashiro, Susanne Ruf, Markus Wolff, Jan Born, Hong-Viet V. Ngo
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	BECTS rolandic epilepsy spikes sleep auditory stimulation sleep spindles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c9fae2ae7f9645e09bf3270293ce47d4
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spelling	oai:doaj.org-article:c9fae2ae7f9645e09bf3270293ce47d42021-11-18T04:52:09ZAuditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes2666-379110.1016/j.xcrm.2021.100432https://doaj.org/article/c9fae2ae7f9645e09bf3270293ce47d42021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666379121002949https://doaj.org/toc/2666-3791Summary: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy linked to diverse cognitive abnormalities. The electroencephalogram of patients shows focal interictal epileptic spikes, particularly during non-rapid eye movement (NonREM) sleep. Spike formation involves thalamocortical networks, which also contribute to the generation of sleep slow oscillations (SOs) and spindles. Motivated by evidence that SO-spindle activity can be controlled through closed-loop auditory stimulation, here, we show in seven patients that auditory stimulation also reduces spike rates in BECTS. Stimulation during NonREM sleep decreases spike rates, with most robust reductions when tones are presented 1.5 to 3.5 s after spikes. Stimulation further reduces the amplitude of spikes closely following tones. Sleep spindles are negatively correlated with spike rates, suggesting that tone-evoked spindle activity mediates the spike suppression. We hypothesize spindle-related refractoriness in thalamocortical circuits as a potential mechanism. Our results open an avenue for the non-pharmacological treatment of BECTS.Jens G. KlinzingLilian TashiroSusanne RufMarkus WolffJan BornHong-Viet V. NgoElsevierarticleBECTSrolandic epilepsyspikessleepauditory stimulationsleep spindlesMedicine (General)R5-920ENCell Reports Medicine, Vol 2, Iss 11, Pp 100432- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BECTS rolandic epilepsy spikes sleep auditory stimulation sleep spindles Medicine (General) R5-920
spellingShingle	BECTS rolandic epilepsy spikes sleep auditory stimulation sleep spindles Medicine (General) R5-920 Jens G. Klinzing Lilian Tashiro Susanne Ruf Markus Wolff Jan Born Hong-Viet V. Ngo Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
description	Summary: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy linked to diverse cognitive abnormalities. The electroencephalogram of patients shows focal interictal epileptic spikes, particularly during non-rapid eye movement (NonREM) sleep. Spike formation involves thalamocortical networks, which also contribute to the generation of sleep slow oscillations (SOs) and spindles. Motivated by evidence that SO-spindle activity can be controlled through closed-loop auditory stimulation, here, we show in seven patients that auditory stimulation also reduces spike rates in BECTS. Stimulation during NonREM sleep decreases spike rates, with most robust reductions when tones are presented 1.5 to 3.5 s after spikes. Stimulation further reduces the amplitude of spikes closely following tones. Sleep spindles are negatively correlated with spike rates, suggesting that tone-evoked spindle activity mediates the spike suppression. We hypothesize spindle-related refractoriness in thalamocortical circuits as a potential mechanism. Our results open an avenue for the non-pharmacological treatment of BECTS.
format	article
author	Jens G. Klinzing Lilian Tashiro Susanne Ruf Markus Wolff Jan Born Hong-Viet V. Ngo
author_facet	Jens G. Klinzing Lilian Tashiro Susanne Ruf Markus Wolff Jan Born Hong-Viet V. Ngo
author_sort	Jens G. Klinzing
title	Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
title_short	Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
title_full	Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
title_fullStr	Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
title_full_unstemmed	Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
title_sort	auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c9fae2ae7f9645e09bf3270293ce47d4
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Auditory stimulation during sleep suppresses spike activity in benign epilepsy with centrotemporal spikes

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