Genus Ziziphus for the treatment of chronic inflammatory diseases

Natural products and traditional medicine are rich sources for developing therapeutics for chronic inflammatory diseases. However, the way from natural products/traditional medicines to Western pharmaceutical practices is not always straightforward. According to the World Health Organization (WHO),...

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Autores principales:	Abdulrhman Alsayari, Shadma Wahab
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ziziphus Chronic inflammatory diseases Cardiovascular disease Neurological disorder Anticancer Antidiabetic Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c9fd1dba14144d96b9b0f2f8234d945f
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spelling	oai:doaj.org-article:c9fd1dba14144d96b9b0f2f8234d945f2021-11-20T04:56:35ZGenus Ziziphus for the treatment of chronic inflammatory diseases1319-562X10.1016/j.sjbs.2021.07.076https://doaj.org/article/c9fd1dba14144d96b9b0f2f8234d945f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21006598https://doaj.org/toc/1319-562XNatural products and traditional medicine are rich sources for developing therapeutics for chronic inflammatory diseases. However, the way from natural products/traditional medicines to Western pharmaceutical practices is not always straightforward. According to the World Health Organization (WHO), chronic diseases are the greatest threat to human health. 3 of 5 people die due to chronic inflammatory disorders worldwide like chronic respiratory diseases, stroke, cardiovascular diseases, cancer, diabetes, and obesity. Various nonsteroidal anti-inflammatory drugs (NSAIDs) are used to reduce inflammation and pain, but there are many side effects of these drugs' administration. Medicinal plants have therapeutic anti-inflammatory effects with low or no side effects. Ziziphus plant species are generally safe and not toxic to humans. Many studies on the Ziziphus species have shown that their therapeutic properties are attributed to the roots, leaves and fruits. Unfortunately, Ziziphus species from different regions worldwide with anti-inflammatory properties have not been documented in a single review paper. Therefore, it is crucial to establish ethnobotanical knowledge and applications of Ziziphus species against chronic inflammatory diseases. The current article exhaustively reviews phytochemical profile, pharmacological studies, toxicological effects, and ethnobotanical uses of Genus Ziziphus in chronic anti-inflammatory diseases. The present review article also highlights the most promising experimental data on Ziziphus extracts and pure compounds active in clinical trials and animal models of chronic inflammatory diseases. This review would be a valuable resource for contemporary researchers in the field to understand the promising role of the Ziziphus genus in chronic inflammatory disorders.Abdulrhman AlsayariShadma WahabElsevierarticleZiziphusChronic inflammatory diseasesCardiovascular diseaseNeurological disorderAnticancerAntidiabeticBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 6897-6914 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ziziphus Chronic inflammatory diseases Cardiovascular disease Neurological disorder Anticancer Antidiabetic Biology (General) QH301-705.5
spellingShingle	Ziziphus Chronic inflammatory diseases Cardiovascular disease Neurological disorder Anticancer Antidiabetic Biology (General) QH301-705.5 Abdulrhman Alsayari Shadma Wahab Genus Ziziphus for the treatment of chronic inflammatory diseases
description	Natural products and traditional medicine are rich sources for developing therapeutics for chronic inflammatory diseases. However, the way from natural products/traditional medicines to Western pharmaceutical practices is not always straightforward. According to the World Health Organization (WHO), chronic diseases are the greatest threat to human health. 3 of 5 people die due to chronic inflammatory disorders worldwide like chronic respiratory diseases, stroke, cardiovascular diseases, cancer, diabetes, and obesity. Various nonsteroidal anti-inflammatory drugs (NSAIDs) are used to reduce inflammation and pain, but there are many side effects of these drugs' administration. Medicinal plants have therapeutic anti-inflammatory effects with low or no side effects. Ziziphus plant species are generally safe and not toxic to humans. Many studies on the Ziziphus species have shown that their therapeutic properties are attributed to the roots, leaves and fruits. Unfortunately, Ziziphus species from different regions worldwide with anti-inflammatory properties have not been documented in a single review paper. Therefore, it is crucial to establish ethnobotanical knowledge and applications of Ziziphus species against chronic inflammatory diseases. The current article exhaustively reviews phytochemical profile, pharmacological studies, toxicological effects, and ethnobotanical uses of Genus Ziziphus in chronic anti-inflammatory diseases. The present review article also highlights the most promising experimental data on Ziziphus extracts and pure compounds active in clinical trials and animal models of chronic inflammatory diseases. This review would be a valuable resource for contemporary researchers in the field to understand the promising role of the Ziziphus genus in chronic inflammatory disorders.
format	article
author	Abdulrhman Alsayari Shadma Wahab
author_facet	Abdulrhman Alsayari Shadma Wahab
author_sort	Abdulrhman Alsayari
title	Genus Ziziphus for the treatment of chronic inflammatory diseases
title_short	Genus Ziziphus for the treatment of chronic inflammatory diseases
title_full	Genus Ziziphus for the treatment of chronic inflammatory diseases
title_fullStr	Genus Ziziphus for the treatment of chronic inflammatory diseases
title_full_unstemmed	Genus Ziziphus for the treatment of chronic inflammatory diseases
title_sort	genus ziziphus for the treatment of chronic inflammatory diseases
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c9fd1dba14144d96b9b0f2f8234d945f
work_keys_str_mv	AT abdulrhmanalsayari genusziziphusforthetreatmentofchronicinflammatorydiseases AT shadmawahab genusziziphusforthetreatmentofchronicinflammatorydiseases
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Genus Ziziphus for the treatment of chronic inflammatory diseases

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