Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

Herberg et al. previously showed functional healing of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates with localized morphogen presentation. In this study, they report the importance of the tubular geometry of MSC condensates in long bone regeneration. Unlike loos...

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Autores principales:	Samuel Herberg, Daniel Varghai, Daniel S. Alt, Phuong N. Dang, Honghyun Park, Yuxuan Cheng, Jung-Youn Shin, Anna D. Dikina, Joel D. Boerckel, Marsha W. Rolle, Eben Alsberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ca034ebc68764f5a85b780ac8aa721e4
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spelling	oai:doaj.org-article:ca034ebc68764f5a85b780ac8aa721e42021-12-02T15:23:27ZScaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration10.1038/s42003-020-01576-y2399-3642https://doaj.org/article/ca034ebc68764f5a85b780ac8aa721e42021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01576-yhttps://doaj.org/toc/2399-3642Herberg et al. previously showed functional healing of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates with localized morphogen presentation. In this study, they report the importance of the tubular geometry of MSC condensates in long bone regeneration. Unlike loosely packed hMSC sheets, only hMSC tubes induced regenerate tissue partially resembling normal growth plate.Samuel HerbergDaniel VarghaiDaniel S. AltPhuong N. DangHonghyun ParkYuxuan ChengJung-Youn ShinAnna D. DikinaJoel D. BoerckelMarsha W. RolleEben AlsbergNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Samuel Herberg Daniel Varghai Daniel S. Alt Phuong N. Dang Honghyun Park Yuxuan Cheng Jung-Youn Shin Anna D. Dikina Joel D. Boerckel Marsha W. Rolle Eben Alsberg Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
description	Herberg et al. previously showed functional healing of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates with localized morphogen presentation. In this study, they report the importance of the tubular geometry of MSC condensates in long bone regeneration. Unlike loosely packed hMSC sheets, only hMSC tubes induced regenerate tissue partially resembling normal growth plate.
format	article
author	Samuel Herberg Daniel Varghai Daniel S. Alt Phuong N. Dang Honghyun Park Yuxuan Cheng Jung-Youn Shin Anna D. Dikina Joel D. Boerckel Marsha W. Rolle Eben Alsberg
author_facet	Samuel Herberg Daniel Varghai Daniel S. Alt Phuong N. Dang Honghyun Park Yuxuan Cheng Jung-Youn Shin Anna D. Dikina Joel D. Boerckel Marsha W. Rolle Eben Alsberg
author_sort	Samuel Herberg
title	Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
title_short	Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
title_full	Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
title_fullStr	Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
title_full_unstemmed	Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
title_sort	scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca034ebc68764f5a85b780ac8aa721e4
work_keys_str_mv	AT samuelherberg scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT danielvarghai scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT danielsalt scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT phuongndang scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT honghyunpark scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT yuxuancheng scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT jungyounshin scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT annaddikina scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT joeldboerckel scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT marshawrolle scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration AT ebenalsberg scaffoldfreehumanmesenchymalstemcellconstructgeometryregulateslongboneregeneration
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Scaffold-free human mesenchymal stem cell construct geometry regulates long bone regeneration

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