Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss

Abstract Blast exposure can induce various types of hearing impairment, including permanent hearing loss, tinnitus, and hyperacusis. Herein, we conducted a detailed investigation of the cochlear pathophysiology in blast-induced hearing loss in mice using two blasts with different characteristics: a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eiko Kimura, Kunio Mizutari, Takaomi Kurioka, Satoko Kawauchi, Yasushi Satoh, Shunichi Sato, Akihiro Shiotani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca036155914349bcba550f27c1c178a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca036155914349bcba550f27c1c178a0
record_format	dspace
spelling	oai:doaj.org-article:ca036155914349bcba550f27c1c178a02021-12-02T16:26:29ZEffect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss10.1038/s41598-021-94080-02045-2322https://doaj.org/article/ca036155914349bcba550f27c1c178a02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94080-0https://doaj.org/toc/2045-2322Abstract Blast exposure can induce various types of hearing impairment, including permanent hearing loss, tinnitus, and hyperacusis. Herein, we conducted a detailed investigation of the cochlear pathophysiology in blast-induced hearing loss in mice using two blasts with different characteristics: a low-frequency dominant blast generated by a shock tube and a high-frequency dominant shock wave generated by laser irradiation (laser-induced shock wave). The pattern of sensorineural hearing loss (SNHL) was low-frequency- and high-frequency-dominant in response to the low- and high-frequency blasts, respectively. Pathological examination revealed that cochlear synaptopathy was the most frequent cochlear pathology after blast exposure, which involved synapse loss in the inner hair cells without hair cell loss, depending on the power spectrum of the blast. This pathological change completely reflected the physiological analysis of wave I amplitude using auditory brainstem responses. Stereociliary bundle disruption in the outer hair cells was also dependent on the blast’s power spectrum. Therefore, we demonstrated that the dominant frequency of the blast power spectrum was the principal factor determining the region of cochlear damage. We believe that the presenting models would be valuable both in blast research and the investigation of various types of hearing loss whose pathogenesis involves cochlear synaptopathy.Eiko KimuraKunio MizutariTakaomi KuriokaSatoko KawauchiYasushi SatohShunichi SatoAkihiro ShiotaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eiko Kimura Kunio Mizutari Takaomi Kurioka Satoko Kawauchi Yasushi Satoh Shunichi Sato Akihiro Shiotani Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
description	Abstract Blast exposure can induce various types of hearing impairment, including permanent hearing loss, tinnitus, and hyperacusis. Herein, we conducted a detailed investigation of the cochlear pathophysiology in blast-induced hearing loss in mice using two blasts with different characteristics: a low-frequency dominant blast generated by a shock tube and a high-frequency dominant shock wave generated by laser irradiation (laser-induced shock wave). The pattern of sensorineural hearing loss (SNHL) was low-frequency- and high-frequency-dominant in response to the low- and high-frequency blasts, respectively. Pathological examination revealed that cochlear synaptopathy was the most frequent cochlear pathology after blast exposure, which involved synapse loss in the inner hair cells without hair cell loss, depending on the power spectrum of the blast. This pathological change completely reflected the physiological analysis of wave I amplitude using auditory brainstem responses. Stereociliary bundle disruption in the outer hair cells was also dependent on the blast’s power spectrum. Therefore, we demonstrated that the dominant frequency of the blast power spectrum was the principal factor determining the region of cochlear damage. We believe that the presenting models would be valuable both in blast research and the investigation of various types of hearing loss whose pathogenesis involves cochlear synaptopathy.
format	article
author	Eiko Kimura Kunio Mizutari Takaomi Kurioka Satoko Kawauchi Yasushi Satoh Shunichi Sato Akihiro Shiotani
author_facet	Eiko Kimura Kunio Mizutari Takaomi Kurioka Satoko Kawauchi Yasushi Satoh Shunichi Sato Akihiro Shiotani
author_sort	Eiko Kimura
title	Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
title_short	Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
title_full	Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
title_fullStr	Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
title_full_unstemmed	Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
title_sort	effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca036155914349bcba550f27c1c178a0
work_keys_str_mv	AT eikokimura effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT kuniomizutari effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT takaomikurioka effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT satokokawauchi effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT yasushisatoh effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT shunichisato effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss AT akihiroshiotani effectofshockwavepowerspectrumontheinnerearpathophysiologyinblastinducedhearingloss
_version_	1718384081398398976

Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss

Ejemplares similares