Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contri...

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Autores principales:	J. Rivera-Correa, J. J. Guthmiller, R. Vijay, C. Fernandez-Arias, M. A. Pardo-Ruge, S. Gonzalez, N. S. Butler, A. Rodriguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca046ba7684d4a96b9538349ba8e7523
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spelling	oai:doaj.org-article:ca046ba7684d4a96b9538349ba8e75232021-12-02T15:39:05ZPlasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria10.1038/s41467-017-01476-62041-1723https://doaj.org/article/ca046ba7684d4a96b9538349ba8e75232017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01476-6https://doaj.org/toc/2041-1723Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contribute to anaemia onset.J. Rivera-CorreaJ. J. GuthmillerR. VijayC. Fernandez-AriasM. A. Pardo-RugeS. GonzalezN. S. ButlerA. RodriguezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Rivera-Correa J. J. Guthmiller R. Vijay C. Fernandez-Arias M. A. Pardo-Ruge S. Gonzalez N. S. Butler A. Rodriguez Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
description	Autoimmune anaemia often accompanies Plasmodium infection and malaria, but how anaemia is induced is still unclear. Here the authors show that Plasmodium DNA, together with interferon-γ, can activate B cells to induce auto-antibodies that recognize red blood cells and promote their removal to contribute to anaemia onset.
format	article
author	J. Rivera-Correa J. J. Guthmiller R. Vijay C. Fernandez-Arias M. A. Pardo-Ruge S. Gonzalez N. S. Butler A. Rodriguez
author_facet	J. Rivera-Correa J. J. Guthmiller R. Vijay C. Fernandez-Arias M. A. Pardo-Ruge S. Gonzalez N. S. Butler A. Rodriguez
author_sort	J. Rivera-Correa
title	Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_short	Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_full	Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_fullStr	Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_full_unstemmed	Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria
title_sort	plasmodium dna-mediated tlr9 activation of t-bet+ b cells contributes to autoimmune anaemia during malaria
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ca046ba7684d4a96b9538349ba8e7523
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Plasmodium DNA-mediated TLR9 activation of T-bet+ B cells contributes to autoimmune anaemia during malaria

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