Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations

How polymorphic elements can drive intra-species variation has not been clearly examined. Here the authors show that the polymorphic GLN endogenous retrovirus (ERV) functions as a cis-regulatory element for neighboring genes, leading to differences in how two mouse strains respond to stress.

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Autores principales:	Xuemeng Zhou, Tsz Wing Sam, Ah Young Lee, Danny Leung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca052e29ec21417699bfcd8d8df14a59
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spelling	oai:doaj.org-article:ca052e29ec21417699bfcd8d8df14a592021-11-14T12:36:01ZMouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations10.1038/s41467-021-26630-z2041-1723https://doaj.org/article/ca052e29ec21417699bfcd8d8df14a592021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26630-zhttps://doaj.org/toc/2041-1723How polymorphic elements can drive intra-species variation has not been clearly examined. Here the authors show that the polymorphic GLN endogenous retrovirus (ERV) functions as a cis-regulatory element for neighboring genes, leading to differences in how two mouse strains respond to stress.Xuemeng ZhouTsz Wing SamAh Young LeeDanny LeungNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuemeng Zhou Tsz Wing Sam Ah Young Lee Danny Leung Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
description	How polymorphic elements can drive intra-species variation has not been clearly examined. Here the authors show that the polymorphic GLN endogenous retrovirus (ERV) functions as a cis-regulatory element for neighboring genes, leading to differences in how two mouse strains respond to stress.
format	article
author	Xuemeng Zhou Tsz Wing Sam Ah Young Lee Danny Leung
author_facet	Xuemeng Zhou Tsz Wing Sam Ah Young Lee Danny Leung
author_sort	Xuemeng Zhou
title	Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
title_short	Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
title_full	Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
title_fullStr	Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
title_full_unstemmed	Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
title_sort	mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca052e29ec21417699bfcd8d8df14a59
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Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations

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