PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight

María A Trak-Fellermeier,1,* Maribel Campos,1,* Marytere Meléndez,1,* Jeremy Pomeroy,2 Cristina Palacios,3 Juana Rivera-Viñas,4 Keimari Méndez,4 Irma Febo,5 Walter Willett,6 Mathew W Gillman,7 Paul W Franks,6,8 Kaumudi Joshipura1,9 1Center for Clinical Res...

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Autores principales:	Trak-Fellermeier MA, Campos M, Meléndez M, Pomeroy J, Palacios C, Rivera-Viñas J, Méndez K, Febo I, Willett W, Gillman MW, Franks PW, Joshipura K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Gestational weight gain Lifestyle modification pregnancy birth weight neonatal Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ca073ebb69594be8aa35bdaa5a734539
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id	oai:doaj.org-article:ca073ebb69594be8aa35bdaa5a734539
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Gestational weight gain Lifestyle modification pregnancy birth weight neonatal Specialties of internal medicine RC581-951
spellingShingle	Gestational weight gain Lifestyle modification pregnancy birth weight neonatal Specialties of internal medicine RC581-951 Trak-Fellermeier MA Campos M Meléndez M Pomeroy J Palacios C Rivera-Viñas J Méndez K Febo I Willett W Gillman MW Franks PW Joshipura K PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
description	María A Trak-Fellermeier,1,* Maribel Campos,1,* Marytere Meléndez,1,* Jeremy Pomeroy,2 Cristina Palacios,3 Juana Rivera-Viñas,4 Keimari Méndez,4 Irma Febo,5 Walter Willett,6 Mathew W Gillman,7 Paul W Franks,6,8 Kaumudi Joshipura1,9 1Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 2Clinical Research Center, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA; 3Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA; 4Department of Obstetrics and Gynecology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 5Department of Pediatrics, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 6Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; 7Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA; 8Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö, Sweden; 9Department of Epidemiology, Harvard T.H. Chan Public Health School, Harvard University, Boston, MA, USA *These authors contributed equally to this work Background: Inappropriate gestational weight gain (GWG) has been associated with adverse perinatal events. High rates of GWG have been reported among Hispanic women. Observational studies indicate that dietary and physical activity interventions during the prenatal period may improve maternal and infant health, but very few randomized trials have been conducted among high-risk overweight/obese Hispanic women. Accordingly, we conducted a lifestyle intervention among high-risk pregnant women and evaluated its impact on achieving appropriate GWG and on improving birthweight.Methods: Eligible overweight/obese women presenting at the University Hospital in Puerto Rico with a singleton pregnancy before 16 gestational weeks were recruited and randomized to lifestyle intervention (n=15) or control group (n=16). The lifestyle intervention focused on improving physical activity and diet quality and optimizing caloric intake. We evaluated the impact of the lifestyle intervention on achieving appropriate GWG and on infant birthweight. Poisson and linear regression analyses were performed. Results: The primary intent to treat analysis showed no significant effect on achievement of appropriate GWG/week through 36 weeks in the intervention group (4/15 women) when compared with the control group (3/16 women) (adjusted incidence rate ratio =1.14; 95% CI: 0.20, 6.67). Although not statistically significant, women in the intervention group (6/15) were 1.7 times more likely to achieve appropriate weekly GWG until delivery when compared with controls (4/16 women) (adjusted incidence rate ratio = 1.67; 95% CI: 0.40, 6.94). We observed lower adjusted birthweight-for-length z-scores in the intervention compared with the control group among male newborns with z-score difference −1.74 (−3.04, −0.43), but not among females −0.83 (−3.85, 2.19). These analyses were adjusted for age and baseline body mass index.Conclusion: Although larger studies are required to determine whether women with obesity may benefit from prenatal lifestyle interventions targeting GWG, our results are suggestive of the intervention improving adherence to established Institute of Medicine guidelines. Keywords: gestational weight gain, lifestyle modification, pregnancy, birthweight, neonatal, randomized controlled trial, overweight, obese, intervention
format	article
author	Trak-Fellermeier MA Campos M Meléndez M Pomeroy J Palacios C Rivera-Viñas J Méndez K Febo I Willett W Gillman MW Franks PW Joshipura K
author_facet	Trak-Fellermeier MA Campos M Meléndez M Pomeroy J Palacios C Rivera-Viñas J Méndez K Febo I Willett W Gillman MW Franks PW Joshipura K
author_sort	Trak-Fellermeier MA
title	PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
title_short	PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
title_full	PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
title_fullStr	PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
title_full_unstemmed	PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
title_sort	pearls randomized lifestyle trial in pregnant hispanic women with overweight/obesity: gestational weight gain and offspring birthweight
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/ca073ebb69594be8aa35bdaa5a734539
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spelling	oai:doaj.org-article:ca073ebb69594be8aa35bdaa5a7345392021-12-02T08:46:11ZPEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight1178-7007https://doaj.org/article/ca073ebb69594be8aa35bdaa5a7345392019-02-01T00:00:00Zhttps://www.dovepress.com/pearls-randomized-lifestyle-trial-in-pregnant-hispanic-women-with-over-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007María A Trak-Fellermeier,1,* Maribel Campos,1,* Marytere Meléndez,1,* Jeremy Pomeroy,2 Cristina Palacios,3 Juana Rivera-Viñas,4 Keimari Méndez,4 Irma Febo,5 Walter Willett,6 Mathew W Gillman,7 Paul W Franks,6,8 Kaumudi Joshipura1,9 1Center for Clinical Research and Health Promotion, School of Dental Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 2Clinical Research Center, Marshfield Clinic Research Institute, Marshfield Clinic Health System, Marshfield, WI, USA; 3Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA; 4Department of Obstetrics and Gynecology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 5Department of Pediatrics, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, USA; 6Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA; 7Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA; 8Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital, Malmö, Sweden; 9Department of Epidemiology, Harvard T.H. Chan Public Health School, Harvard University, Boston, MA, USA *These authors contributed equally to this work Background: Inappropriate gestational weight gain (GWG) has been associated with adverse perinatal events. High rates of GWG have been reported among Hispanic women. Observational studies indicate that dietary and physical activity interventions during the prenatal period may improve maternal and infant health, but very few randomized trials have been conducted among high-risk overweight/obese Hispanic women. Accordingly, we conducted a lifestyle intervention among high-risk pregnant women and evaluated its impact on achieving appropriate GWG and on improving birthweight.Methods: Eligible overweight/obese women presenting at the University Hospital in Puerto Rico with a singleton pregnancy before 16 gestational weeks were recruited and randomized to lifestyle intervention (n=15) or control group (n=16). The lifestyle intervention focused on improving physical activity and diet quality and optimizing caloric intake. We evaluated the impact of the lifestyle intervention on achieving appropriate GWG and on infant birthweight. Poisson and linear regression analyses were performed. Results: The primary intent to treat analysis showed no significant effect on achievement of appropriate GWG/week through 36 weeks in the intervention group (4/15 women) when compared with the control group (3/16 women) (adjusted incidence rate ratio =1.14; 95% CI: 0.20, 6.67). Although not statistically significant, women in the intervention group (6/15) were 1.7 times more likely to achieve appropriate weekly GWG until delivery when compared with controls (4/16 women) (adjusted incidence rate ratio = 1.67; 95% CI: 0.40, 6.94). We observed lower adjusted birthweight-for-length z-scores in the intervention compared with the control group among male newborns with z-score difference −1.74 (−3.04, −0.43), but not among females −0.83 (−3.85, 2.19). These analyses were adjusted for age and baseline body mass index.Conclusion: Although larger studies are required to determine whether women with obesity may benefit from prenatal lifestyle interventions targeting GWG, our results are suggestive of the intervention improving adherence to established Institute of Medicine guidelines. Keywords: gestational weight gain, lifestyle modification, pregnancy, birthweight, neonatal, randomized controlled trial, overweight, obese, interventionTrak-Fellermeier MACampos MMeléndez MPomeroy JPalacios CRivera-Viñas JMéndez KFebo IWillett WGillman MWFranks PWJoshipura KDove Medical PressarticleGestational weight gainLifestyle modificationpregnancybirth weightneonatalSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 225-238 (2019)

PEARLS randomized lifestyle trial in pregnant Hispanic women with overweight/obesity: gestational weight gain and offspring birthweight

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