mtDNA in the Pathogenesis of Cardiovascular Diseases

The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of r...

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Autores principales:	Lili Wang, Qianhui Zhang, Kexin Yuan, Jing Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca07dc9f9cf44c30a87eba1066f006c5
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spelling	oai:doaj.org-article:ca07dc9f9cf44c30a87eba1066f006c52021-11-22T01:09:33ZmtDNA in the Pathogenesis of Cardiovascular Diseases1875-863010.1155/2021/7157109https://doaj.org/article/ca07dc9f9cf44c30a87eba1066f006c52021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7157109https://doaj.org/toc/1875-8630The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of research, more and more evidence showed that mtDNA is related to the occurrence and development of CVD. Current studies mainly focus on how mtDNA copy number, an indirect biomarker of mitochondrial function, contributes to CVD and its underlying mechanisms including mtDNA autophagy, the effect of mtDNA on cardiac inflammation, and related metabolic functions. However, no relevant studies have been conducted yet. In this paper, we combed the current research status of the mechanism related to the influence of mtDNA on the occurrence, development, and prognosis of CVD, so as to find whether these mechanisms have something in common, or is there a correlation between each mechanism for the development of CVD?Lili WangQianhui ZhangKexin YuanJing YuanHindawi LimitedarticleMedicine (General)R5-920ENDisease Markers, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lili Wang Qianhui Zhang Kexin Yuan Jing Yuan mtDNA in the Pathogenesis of Cardiovascular Diseases
description	The incidence rate of cardiovascular disease (CVD) has been increasing year by year and has become the main cause for the increase of mortality. Mitochondrial DNA (mtDNA) plays a crucial role in the pathogenesis of CVD, especially in heart failure and ischemic heart diseases. With the deepening of research, more and more evidence showed that mtDNA is related to the occurrence and development of CVD. Current studies mainly focus on how mtDNA copy number, an indirect biomarker of mitochondrial function, contributes to CVD and its underlying mechanisms including mtDNA autophagy, the effect of mtDNA on cardiac inflammation, and related metabolic functions. However, no relevant studies have been conducted yet. In this paper, we combed the current research status of the mechanism related to the influence of mtDNA on the occurrence, development, and prognosis of CVD, so as to find whether these mechanisms have something in common, or is there a correlation between each mechanism for the development of CVD?
format	article
author	Lili Wang Qianhui Zhang Kexin Yuan Jing Yuan
author_facet	Lili Wang Qianhui Zhang Kexin Yuan Jing Yuan
author_sort	Lili Wang
title	mtDNA in the Pathogenesis of Cardiovascular Diseases
title_short	mtDNA in the Pathogenesis of Cardiovascular Diseases
title_full	mtDNA in the Pathogenesis of Cardiovascular Diseases
title_fullStr	mtDNA in the Pathogenesis of Cardiovascular Diseases
title_full_unstemmed	mtDNA in the Pathogenesis of Cardiovascular Diseases
title_sort	mtdna in the pathogenesis of cardiovascular diseases
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ca07dc9f9cf44c30a87eba1066f006c5
work_keys_str_mv	AT liliwang mtdnainthepathogenesisofcardiovasculardiseases AT qianhuizhang mtdnainthepathogenesisofcardiovasculardiseases AT kexinyuan mtdnainthepathogenesisofcardiovasculardiseases AT jingyuan mtdnainthepathogenesisofcardiovasculardiseases
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mtDNA in the Pathogenesis of Cardiovascular Diseases

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