Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, so...

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Autores principales:	Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Żera
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxytocin vasopressin hypertension myocardial infarction stress Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ca08fa6e6f4040b1aabddb4b719c4eb9
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spelling	oai:doaj.org-article:ca08fa6e6f4040b1aabddb4b719c4eb92021-11-11T16:55:37ZComplementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation10.3390/ijms2221114651422-00671661-6596https://doaj.org/article/ca08fa6e6f4040b1aabddb4b719c4eb92021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11465https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.Ewa Szczepanska-SadowskaAgnieszka WsolAgnieszka Cudnoch-JedrzejewskaTymoteusz ŻeraMDPI AGarticleoxytocinvasopressinhypertensionmyocardial infarctionstressBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11465, p 11465 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin vasopressin hypertension myocardial infarction stress Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	oxytocin vasopressin hypertension myocardial infarction stress Biology (General) QH301-705.5 Chemistry QD1-999 Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
description	The neurons secreting oxytocin (OXY) and vasopressin (AVP) are located mainly in the supraoptic, paraventricular, and suprachiasmatic nucleus of the brain. Oxytocinergic and vasopressinergic projections reach several regions of the brain and the spinal cord. Both peptides are released from axons, soma, and dendrites and modulate the excitability of other neuroregulatory pathways. The synthesis and action of OXY and AVP in the peripheral organs (eye, heart, gastrointestinal system) is being investigated. The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. Vasopressin interacts with three subtypes of receptors: V1aR, V1bR, and V2R whereas oxytocin activates its own OXTR and V1aR receptors. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors. The inappropriate regulation of oxytocin and vasopressin secretion during ischemia, hypoxia/hypercapnia, inflammation, pain, and stress may play a significant role in the pathogenesis of cardiovascular diseases.
format	article
author	Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera
author_facet	Ewa Szczepanska-Sadowska Agnieszka Wsol Agnieszka Cudnoch-Jedrzejewska Tymoteusz Żera
author_sort	Ewa Szczepanska-Sadowska
title	Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
title_short	Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
title_full	Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
title_fullStr	Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
title_full_unstemmed	Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation
title_sort	complementary role of oxytocin and vasopressin in cardiovascular regulation
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca08fa6e6f4040b1aabddb4b719c4eb9
work_keys_str_mv	AT ewaszczepanskasadowska complementaryroleofoxytocinandvasopressinincardiovascularregulation AT agnieszkawsol complementaryroleofoxytocinandvasopressinincardiovascularregulation AT agnieszkacudnochjedrzejewska complementaryroleofoxytocinandvasopressinincardiovascularregulation AT tymoteuszzera complementaryroleofoxytocinandvasopressinincardiovascularregulation
_version_	1718432203298308096

Complementary Role of Oxytocin and Vasopressin in Cardiovascular Regulation

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