Barium titanate core – gold shell nanoparticles for hyperthermia treatments

Barium titanate core – gold shell nanoparticles for hyperthermia treatments

Elmira FarrokhTakin,1,2 Gianni Ciofani,1 Gian Luigi Puleo,1 Giuseppe de Vito,3,4 Carlo Filippeschi,1 Barbara Mazzolai,1 Vincenzo Piazza,3 Virgilio Mattoli1 1Center for Micro-BioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera, Pisa, Italy; 2The Biorobotics Institute, Scuola Supe...

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Autores principales: FarrokhTakin E, Ciofani G, Puleo GL, de Vito G, Filippeschi C, Mazzolai B, Piazza V, Mattoli V
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/ca0ad0d53d3c460d951c0759977760ae
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spelling oai:doaj.org-article:ca0ad0d53d3c460d951c0759977760ae2021-12-02T01:32:22ZBarium titanate core – gold shell nanoparticles for hyperthermia treatments1176-91141178-2013https://doaj.org/article/ca0ad0d53d3c460d951c0759977760ae2013-06-01T00:00:00Zhttp://www.dovepress.com/barium-titanate-core-ndash-gold-shell-nanoparticles-for-hyperthermia-t-a13491https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Elmira FarrokhTakin,1,2 Gianni Ciofani,1 Gian Luigi Puleo,1 Giuseppe de Vito,3,4 Carlo Filippeschi,1 Barbara Mazzolai,1 Vincenzo Piazza,3 Virgilio Mattoli1 1Center for Micro-BioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera, Pisa, Italy; 2The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Pisa, Italy; 3Center for Nanotechnology Innovation @NEST, Fondazione Istituto Italiano di Tecnologia, Pisa, Italy; 4NEST, Scuola Normale Superiore, Pisa, Italy Abstract: The development of new tools and devices to aid in treating cancer is a hot topic in biomedical research. The practice of using heat (hyperthermia) to treat cancerous lesions has a long history dating back to ancient Greece. With deeper knowledge of the factors that cause cancer and the transmissive window of cells and tissues in the near-infrared region of the electromagnetic spectrum, hyperthermia applications have been able to incorporate the use of lasers. Photothermal therapy has been introduced as a selective and noninvasive treatment for cancer, in which exogenous photothermal agents are exploited to achieve the selective destruction of cancer cells. In this manuscript, we propose applications of barium titanate core–gold shell nanoparticles for hyperthermia treatment against cancer cells. We explored the effect of increasing concentrations of these nanoshells (0–100 µg/mL) on human neuroblastoma SH-SY5Y cells, testing the internalization and intrinsic toxicity and validating the hyperthermic functionality of the particles through near infrared (NIR) laser-induced thermoablation experiments. No significant changes were observed in cell viability up to nanoparticle concentrations of 50 µg/mL. Experiments upon stimulation with an NIR laser revealed the ability of the nanoshells to destroy human neuroblastoma cells. On the basis of these findings, barium titanate core–gold shell nanoparticles resulted in being suitable for hyperthermia treatment, and our results represent a promising first step for subsequent investigations on their applicability in clinical practice. Keywords: barium titanate nanoparticles, gold nanoshells, NIR stimulation, human neuroblastomaFarrokhTakin ECiofani GPuleo GLde Vito GFilippeschi CMazzolai BPiazza VMattoli VDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 2319-2331 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
FarrokhTakin E
Ciofani G
Puleo GL
de Vito G
Filippeschi C
Mazzolai B
Piazza V
Mattoli V
Barium titanate core – gold shell nanoparticles for hyperthermia treatments
description Elmira FarrokhTakin,1,2 Gianni Ciofani,1 Gian Luigi Puleo,1 Giuseppe de Vito,3,4 Carlo Filippeschi,1 Barbara Mazzolai,1 Vincenzo Piazza,3 Virgilio Mattoli1 1Center for Micro-BioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera, Pisa, Italy; 2The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Pisa, Italy; 3Center for Nanotechnology Innovation @NEST, Fondazione Istituto Italiano di Tecnologia, Pisa, Italy; 4NEST, Scuola Normale Superiore, Pisa, Italy Abstract: The development of new tools and devices to aid in treating cancer is a hot topic in biomedical research. The practice of using heat (hyperthermia) to treat cancerous lesions has a long history dating back to ancient Greece. With deeper knowledge of the factors that cause cancer and the transmissive window of cells and tissues in the near-infrared region of the electromagnetic spectrum, hyperthermia applications have been able to incorporate the use of lasers. Photothermal therapy has been introduced as a selective and noninvasive treatment for cancer, in which exogenous photothermal agents are exploited to achieve the selective destruction of cancer cells. In this manuscript, we propose applications of barium titanate core–gold shell nanoparticles for hyperthermia treatment against cancer cells. We explored the effect of increasing concentrations of these nanoshells (0–100 µg/mL) on human neuroblastoma SH-SY5Y cells, testing the internalization and intrinsic toxicity and validating the hyperthermic functionality of the particles through near infrared (NIR) laser-induced thermoablation experiments. No significant changes were observed in cell viability up to nanoparticle concentrations of 50 µg/mL. Experiments upon stimulation with an NIR laser revealed the ability of the nanoshells to destroy human neuroblastoma cells. On the basis of these findings, barium titanate core–gold shell nanoparticles resulted in being suitable for hyperthermia treatment, and our results represent a promising first step for subsequent investigations on their applicability in clinical practice. Keywords: barium titanate nanoparticles, gold nanoshells, NIR stimulation, human neuroblastoma
format article
author FarrokhTakin E
Ciofani G
Puleo GL
de Vito G
Filippeschi C
Mazzolai B
Piazza V
Mattoli V
author_facet FarrokhTakin E
Ciofani G
Puleo GL
de Vito G
Filippeschi C
Mazzolai B
Piazza V
Mattoli V
author_sort FarrokhTakin E
title Barium titanate core – gold shell nanoparticles for hyperthermia treatments
title_short Barium titanate core – gold shell nanoparticles for hyperthermia treatments
title_full Barium titanate core – gold shell nanoparticles for hyperthermia treatments
title_fullStr Barium titanate core – gold shell nanoparticles for hyperthermia treatments
title_full_unstemmed Barium titanate core – gold shell nanoparticles for hyperthermia treatments
title_sort barium titanate core – gold shell nanoparticles for hyperthermia treatments
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/ca0ad0d53d3c460d951c0759977760ae
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