Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.

Tumor development is accompanied by a complex host systemic response, which includes inflammatory and angiogenic reactions. Both tumor-derived and systemic response proteins are detected in plasma from cancer patients. However, given their non-specific nature, systemic response proteins can confound...

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Autores principales:	Karen S Kelly-Spratt, Sharon J Pitteri, Kay E Gurley, Denny Liggitt, Alice Chin, Jacob Kennedy, Chee-Hong Wong, Qing Zhang, Tina Busald Buson, Hong Wang, Samir M Hanash, Christopher J Kemp
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca0f0a69bff64f8fbe055b6d96b1ab09
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spelling	oai:doaj.org-article:ca0f0a69bff64f8fbe055b6d96b1ab092021-11-18T06:54:07ZPlasma proteome profiles associated with inflammation, angiogenesis, and cancer.1932-620310.1371/journal.pone.0019721https://doaj.org/article/ca0f0a69bff64f8fbe055b6d96b1ab092011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589862/?tool=EBIhttps://doaj.org/toc/1932-6203Tumor development is accompanied by a complex host systemic response, which includes inflammatory and angiogenic reactions. Both tumor-derived and systemic response proteins are detected in plasma from cancer patients. However, given their non-specific nature, systemic response proteins can confound the detection or diagnosis of neoplasia. Here, we have applied an in-depth quantitative proteomic approach to analyze plasma protein changes in mouse models of subacute irritant-driven inflammation, autoreactive inflammation, and matrix associated angiogenesis and compared results to previously described findings from mouse models of polyoma middle T-driven breast cancer and Pdx1-Cre Kras(G12D) Ink4a/Arf (lox/lox)-induced pancreatic cancer. Among the confounding models, approximately 1/3 of all quantified plasma proteins exhibited a significant change in abundance compared to control mice. Of the proteins that changed in abundance, the majority were unique to each model. Altered proteins included those involved in acute phase response, inflammation, extracellular matrix remodeling, angiogenesis, and TGFβ signaling. Comparison of changes in plasma proteins between the confounder models and the two cancer models revealed proteins that were restricted to the cancer-bearing mice, reflecting the known biology of these tumors. This approach provides a basis for distinguishing between protein changes in plasma that are cancer-related and those that are part of a non-specific host response.Karen S Kelly-SprattSharon J PitteriKay E GurleyDenny LiggittAlice ChinJacob KennedyChee-Hong WongQing ZhangTina Busald BusonHong WangSamir M HanashChristopher J KempPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19721 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karen S Kelly-Spratt Sharon J Pitteri Kay E Gurley Denny Liggitt Alice Chin Jacob Kennedy Chee-Hong Wong Qing Zhang Tina Busald Buson Hong Wang Samir M Hanash Christopher J Kemp Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
description	Tumor development is accompanied by a complex host systemic response, which includes inflammatory and angiogenic reactions. Both tumor-derived and systemic response proteins are detected in plasma from cancer patients. However, given their non-specific nature, systemic response proteins can confound the detection or diagnosis of neoplasia. Here, we have applied an in-depth quantitative proteomic approach to analyze plasma protein changes in mouse models of subacute irritant-driven inflammation, autoreactive inflammation, and matrix associated angiogenesis and compared results to previously described findings from mouse models of polyoma middle T-driven breast cancer and Pdx1-Cre Kras(G12D) Ink4a/Arf (lox/lox)-induced pancreatic cancer. Among the confounding models, approximately 1/3 of all quantified plasma proteins exhibited a significant change in abundance compared to control mice. Of the proteins that changed in abundance, the majority were unique to each model. Altered proteins included those involved in acute phase response, inflammation, extracellular matrix remodeling, angiogenesis, and TGFβ signaling. Comparison of changes in plasma proteins between the confounder models and the two cancer models revealed proteins that were restricted to the cancer-bearing mice, reflecting the known biology of these tumors. This approach provides a basis for distinguishing between protein changes in plasma that are cancer-related and those that are part of a non-specific host response.
format	article
author	Karen S Kelly-Spratt Sharon J Pitteri Kay E Gurley Denny Liggitt Alice Chin Jacob Kennedy Chee-Hong Wong Qing Zhang Tina Busald Buson Hong Wang Samir M Hanash Christopher J Kemp
author_facet	Karen S Kelly-Spratt Sharon J Pitteri Kay E Gurley Denny Liggitt Alice Chin Jacob Kennedy Chee-Hong Wong Qing Zhang Tina Busald Buson Hong Wang Samir M Hanash Christopher J Kemp
author_sort	Karen S Kelly-Spratt
title	Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
title_short	Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
title_full	Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
title_fullStr	Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
title_full_unstemmed	Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
title_sort	plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ca0f0a69bff64f8fbe055b6d96b1ab09
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Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.

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