Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution
Sheila Thampi,1 Steven W Hetts,3 Daniel L Cooke,3 Paul J Stewart,2 Elizabeth Robbins,1 Anuradha Banerjee,1 Steven G DuBois,1 Devron Char,2 Van Halbach,3 Katherine Matthay11Department of Pediatrics, 2Department of Ophthalmology, 3Department of Radiology and Biomedical Imaging, Division of Neurointerv...
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Dove Medical Press
2013
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oai:doaj.org-article:ca1480cb59c0434bba136ce4f56eda1f2021-12-02T05:00:05ZSuperselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution1177-54671177-5483https://doaj.org/article/ca1480cb59c0434bba136ce4f56eda1f2013-05-01T00:00:00Zhttp://www.dovepress.com/superselective-intra-arterial-melphalan-therapy-for-newly-diagnosed-an-a13156https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Sheila Thampi,1 Steven W Hetts,3 Daniel L Cooke,3 Paul J Stewart,2 Elizabeth Robbins,1 Anuradha Banerjee,1 Steven G DuBois,1 Devron Char,2 Van Halbach,3 Katherine Matthay11Department of Pediatrics, 2Department of Ophthalmology, 3Department of Radiology and Biomedical Imaging, Division of Neurointerventional Radiology, University of California, San Francisco School of Medicine, San Francisco, CA, USABackground: Intra-arterial administration of melphalan chemotherapy has shown promise in the treatment of retinoblastoma. This report describes our results using superselective intra-arterial melphalan in patients with newly diagnosed retinoblastoma and those who were treated for progression after systemic chemotherapy.Methods: This is a retrospective review of all retinoblastoma patients treated with intra-arterial melphalan at the University of California, San Francisco from March 2010 to August 2012. Twenty eyes (16 patients) underwent 40 intra-arterial melphalan infusions, and dose was determined by age. Patients were treated at monthly intervals and received a range of 1–5 treatments. Response to therapy, toxicity, and procedural radiation exposure was assessed.Results: All patients are alive without metastatic disease at a median follow-up of 14.5 (1–29) months. Treatment with enucleation or external beam radiation was avoided in 11/20 eyes (55%) overall [6/12 (50%) in newly diagnosed eyes and 5/8 (63%) in refractory/relapsed eyes]. Response rates (per the International Classification of Retinoblastoma) were as follows: 6/7 (86%) in groups A–C and 5/13 (38%) in groups D and E. Nonhematologic and hematologic toxicities were minimal and comparable with those in previous reports. The mean procedural radiation dose was 20.2 ± 11.9 mGy per eye per procedure.Conclusion: Superselective intra-arterial melphalan therapy is effective for less advanced eyes but further modifications to therapy are required to improve results in eyes with advanced retinoblastoma.Keywords: retinoblastoma, intra-arterial, melphalanThampi SHetts SWCooke DLStewart PJRobbins EBanerjee ADuBois SGChar DHalbach VMatthay KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 981-989 (2013) |
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Ophthalmology RE1-994 |
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Ophthalmology RE1-994 Thampi S Hetts SW Cooke DL Stewart PJ Robbins E Banerjee A DuBois SG Char D Halbach V Matthay K Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| description |
Sheila Thampi,1 Steven W Hetts,3 Daniel L Cooke,3 Paul J Stewart,2 Elizabeth Robbins,1 Anuradha Banerjee,1 Steven G DuBois,1 Devron Char,2 Van Halbach,3 Katherine Matthay11Department of Pediatrics, 2Department of Ophthalmology, 3Department of Radiology and Biomedical Imaging, Division of Neurointerventional Radiology, University of California, San Francisco School of Medicine, San Francisco, CA, USABackground: Intra-arterial administration of melphalan chemotherapy has shown promise in the treatment of retinoblastoma. This report describes our results using superselective intra-arterial melphalan in patients with newly diagnosed retinoblastoma and those who were treated for progression after systemic chemotherapy.Methods: This is a retrospective review of all retinoblastoma patients treated with intra-arterial melphalan at the University of California, San Francisco from March 2010 to August 2012. Twenty eyes (16 patients) underwent 40 intra-arterial melphalan infusions, and dose was determined by age. Patients were treated at monthly intervals and received a range of 1–5 treatments. Response to therapy, toxicity, and procedural radiation exposure was assessed.Results: All patients are alive without metastatic disease at a median follow-up of 14.5 (1–29) months. Treatment with enucleation or external beam radiation was avoided in 11/20 eyes (55%) overall [6/12 (50%) in newly diagnosed eyes and 5/8 (63%) in refractory/relapsed eyes]. Response rates (per the International Classification of Retinoblastoma) were as follows: 6/7 (86%) in groups A–C and 5/13 (38%) in groups D and E. Nonhematologic and hematologic toxicities were minimal and comparable with those in previous reports. The mean procedural radiation dose was 20.2 ± 11.9 mGy per eye per procedure.Conclusion: Superselective intra-arterial melphalan therapy is effective for less advanced eyes but further modifications to therapy are required to improve results in eyes with advanced retinoblastoma.Keywords: retinoblastoma, intra-arterial, melphalan |
| format |
article |
| author |
Thampi S Hetts SW Cooke DL Stewart PJ Robbins E Banerjee A DuBois SG Char D Halbach V Matthay K |
| author_facet |
Thampi S Hetts SW Cooke DL Stewart PJ Robbins E Banerjee A DuBois SG Char D Halbach V Matthay K |
| author_sort |
Thampi S |
| title |
Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| title_short |
Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| title_full |
Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| title_fullStr |
Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| title_full_unstemmed |
Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| title_sort |
superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/ca1480cb59c0434bba136ce4f56eda1f |
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