Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.

In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequenc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yan Wang, Jing Xue, Xuedong Zhou, Meng You, Qin Du, Xue Yang, Jinzhi He, Jing Zou, Lei Cheng, Mingyun Li, Yuqing Li, Yiping Zhu, Jiyao Li, Wenyuan Shi, Xin Xu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca166965c95445c19b668c811ae7c57f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca166965c95445c19b668c811ae7c57f
record_format	dspace
spelling	oai:doaj.org-article:ca166965c95445c19b668c811ae7c57f2021-11-25T06:08:26ZOral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.1932-620310.1371/journal.pone.0102116https://doaj.org/article/ca166965c95445c19b668c811ae7c57f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25025462/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order Lactobacillales, the Family Aerococcaceae and Carnobacteriaceae, as well as the Genus Abiotrophia and Granulicatella were associated with leukemia status. ALL patients demonstrated a structural imbalance of the oral microbiota, characterized by reduced diversity and abundance alterations, possibly involved in systemic infections, indicating the importance of immune status in shaping the structure of oral microbiota.Yan WangJing XueXuedong ZhouMeng YouQin DuXue YangJinzhi HeJing ZouLei ChengMingyun LiYuqing LiYiping ZhuJiyao LiWenyuan ShiXin XuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102116 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Wang Jing Xue Xuedong Zhou Meng You Qin Du Xue Yang Jinzhi He Jing Zou Lei Cheng Mingyun Li Yuqing Li Yiping Zhu Jiyao Li Wenyuan Shi Xin Xu Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
description	In leukemia, oral manifestations indicate aberrations in oral microbiota. Microbiota structure is determined by both host and environmental factors. In human hosts, how health status shapes the composition of oral microbiota is largely unknown. Taking advantage of advances in high-throughput sequencing, we compared the composition of supragingival plaque microbiota of acute lymphoblastic leukemia (ALL) pediatric patients with healthy controls. The oral microbiota of leukemia patients had lower richness and less diversity compared to healthy controls. Microbial samples clustered into two major groups, one of ALL patients and another of healthy children, with different structure and composition. Abundance changes of certain taxa including the Phylum Firmicutes, the Class Bacilli, the Order Lactobacillales, the Family Aerococcaceae and Carnobacteriaceae, as well as the Genus Abiotrophia and Granulicatella were associated with leukemia status. ALL patients demonstrated a structural imbalance of the oral microbiota, characterized by reduced diversity and abundance alterations, possibly involved in systemic infections, indicating the importance of immune status in shaping the structure of oral microbiota.
format	article
author	Yan Wang Jing Xue Xuedong Zhou Meng You Qin Du Xue Yang Jinzhi He Jing Zou Lei Cheng Mingyun Li Yuqing Li Yiping Zhu Jiyao Li Wenyuan Shi Xin Xu
author_facet	Yan Wang Jing Xue Xuedong Zhou Meng You Qin Du Xue Yang Jinzhi He Jing Zou Lei Cheng Mingyun Li Yuqing Li Yiping Zhu Jiyao Li Wenyuan Shi Xin Xu
author_sort	Yan Wang
title	Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
title_short	Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
title_full	Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
title_fullStr	Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
title_full_unstemmed	Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
title_sort	oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ca166965c95445c19b668c811ae7c57f
work_keys_str_mv	AT yanwang oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT jingxue oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT xuedongzhou oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT mengyou oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT qindu oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT xueyang oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT jinzhihe oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT jingzou oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT leicheng oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT mingyunli oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT yuqingli oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT yipingzhu oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT jiyaoli oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT wenyuanshi oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations AT xinxu oralmicrobiotadistinguishesacutelymphoblasticleukemiapediatrichostsfromhealthypopulations
_version_	1718414130462851072

Oral microbiota distinguishes acute lymphoblastic leukemia pediatric hosts from healthy populations.

Ejemplares similares