Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention

Valery Danilenko,1 Andrey Devyatkin,2 Mariya Marsova,1 Madina Shibilova,3 Rustem Ilyasov,1 Vladimir Shmyrev4 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; 2Central Clinical Hospital with a Polyclinic CMP RF, Moscow, Russia; 3Polyclinic No. 1 CMP RF, Moscow, Rus...

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Autores principales: Danilenko V, Devyatkin A, Marsova M, Shibilova M, Ilyasov R, Shmyrev V
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
renin-angiotensin-aldosterone system
gut microbiome
coronavirus infection
covid-19
neurodegenerative diseases
inflammatory processes
oxidative stress
pharmabiotics
probiotics
postbiotics
plant-based symbiotics
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/ca1f28bdce7f4f49a5e1586f5ea94fb1
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spelling oai:doaj.org-article:ca1f28bdce7f4f49a5e1586f5ea94fb12021-11-30T18:50:37ZCommon Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention1178-7031https://doaj.org/article/ca1f28bdce7f4f49a5e1586f5ea94fb12021-11-01T00:00:00Zhttps://www.dovepress.com/common-inflammatory-mechanisms-in-covid-19-and-parkinsons-diseases-the-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Valery Danilenko,1 Andrey Devyatkin,2 Mariya Marsova,1 Madina Shibilova,3 Rustem Ilyasov,1 Vladimir Shmyrev4 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; 2Central Clinical Hospital with a Polyclinic CMP RF, Moscow, Russia; 3Polyclinic No. 1 CMP RF, Moscow, Russia; 4Central State Medical Academy CMP RF, Moscow, RussiaCorrespondence: Rustem Ilyasov Email apismell@hotmail.comAbstract: In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin–angiotensin–aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and next-generation probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.Keywords: renin–angiotensin–aldosterone system, gut microbiome, coronavirus infection, COVID-19, neurodegenerative diseases, inflammatory processes, oxidative stress, pharmabiotics, probiotics, postbiotics, symbiotics, LactobacillusDanilenko VDevyatkin AMarsova MShibilova MIlyasov RShmyrev VDove Medical Pressarticlerenin-angiotensin-aldosterone systemgut microbiomecoronavirus infectioncovid-19neurodegenerative diseasesinflammatory processesoxidative stresspharmabioticsprobioticspostbioticsplant-based symbioticsPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 6349-6381 (2021)
institution DOAJ
collection DOAJ
language EN
topic renin-angiotensin-aldosterone system
gut microbiome
coronavirus infection
covid-19
neurodegenerative diseases
inflammatory processes
oxidative stress
pharmabiotics
probiotics
postbiotics
plant-based symbiotics
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
spellingShingle renin-angiotensin-aldosterone system
gut microbiome
coronavirus infection
covid-19
neurodegenerative diseases
inflammatory processes
oxidative stress
pharmabiotics
probiotics
postbiotics
plant-based symbiotics
Pathology
RB1-214
Therapeutics. Pharmacology
RM1-950
Danilenko V
Devyatkin A
Marsova M
Shibilova M
Ilyasov R
Shmyrev V
Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
description Valery Danilenko,1 Andrey Devyatkin,2 Mariya Marsova,1 Madina Shibilova,3 Rustem Ilyasov,1 Vladimir Shmyrev4 1Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia; 2Central Clinical Hospital with a Polyclinic CMP RF, Moscow, Russia; 3Polyclinic No. 1 CMP RF, Moscow, Russia; 4Central State Medical Academy CMP RF, Moscow, RussiaCorrespondence: Rustem Ilyasov Email apismell@hotmail.comAbstract: In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin–angiotensin–aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and next-generation probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.Keywords: renin–angiotensin–aldosterone system, gut microbiome, coronavirus infection, COVID-19, neurodegenerative diseases, inflammatory processes, oxidative stress, pharmabiotics, probiotics, postbiotics, symbiotics, Lactobacillus
format article
author Danilenko V
Devyatkin A
Marsova M
Shibilova M
Ilyasov R
Shmyrev V
author_facet Danilenko V
Devyatkin A
Marsova M
Shibilova M
Ilyasov R
Shmyrev V
author_sort Danilenko V
title Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
title_short Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
title_full Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
title_fullStr Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
title_full_unstemmed Common Inflammatory Mechanisms in COVID-19 and Parkinson’s Diseases: The Role of Microbiome, Pharmabiotics and Postbiotics in Their Prevention
title_sort common inflammatory mechanisms in covid-19 and parkinson’s diseases: the role of microbiome, pharmabiotics and postbiotics in their prevention
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/ca1f28bdce7f4f49a5e1586f5ea94fb1
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