Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

Abstract Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap b...

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Autores principales:	Richard Pasteka, Mathias Forjan, Stefan Sauermann, Andreas Drauschke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca20b7fcb4e4468db850a02f37ca040d
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spelling	oai:doaj.org-article:ca20b7fcb4e4468db850a02f37ca040d2021-12-02T13:35:12ZElectro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation10.1038/s41598-019-56176-62045-2322https://doaj.org/article/ca20b7fcb4e4468db850a02f37ca040d2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56176-6https://doaj.org/toc/2045-2322Abstract Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation \|3σ\| for both, simplified lung equivalents ($${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$ µV̇ = 23.98 ± 1.04 l/min, μP = −0.78 ± 0.63 hPa) and primed porcine lungs ($${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$ µV̇ = 18.87 ± 2.49 l/min, μP = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.Richard PastekaMathias ForjanStefan SauermannAndreas DrauschkeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard Pasteka Mathias Forjan Stefan Sauermann Andreas Drauschke Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
description	Abstract Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real anatomical environment and the safe, cost-effective simulation methods. The presented electro-mechanical lung simulator, xPULM, combines in-silico, ex-vivo and mechanical respiratory approaches by realistically replicating an actively breathing human lung. The reproducibility of sinusoidal breathing simulations with xPULM was verified for selected breathing frequencies (10–18 bpm) and tidal volumes (400–600 ml) physiologically occurring during human breathing at rest. Human lung anatomy was modelled using latex bags and primed porcine lungs. High reproducibility of flow and pressure characteristics was shown by evaluating breathing cycles (nTotal = 3273) with highest standard deviation \|3σ\| for both, simplified lung equivalents ($${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$ µV̇ = 23.98 ± 1.04 l/min, μP = −0.78 ± 0.63 hPa) and primed porcine lungs ($${{\boldsymbol{\mu }}}_{\dot{{\bf{V}}}}$$ µV̇ = 18.87 ± 2.49 l/min, μP = −21.13 ± 1.47 hPa). The adaptability of the breathing simulation parameters, coupled with the use of porcine lungs salvaged from a slaughterhouse process, represents an advancement towards anatomically and physiologically realistic modelling of human respiration.
format	article
author	Richard Pasteka Mathias Forjan Stefan Sauermann Andreas Drauschke
author_facet	Richard Pasteka Mathias Forjan Stefan Sauermann Andreas Drauschke
author_sort	Richard Pasteka
title	Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
title_short	Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
title_full	Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
title_fullStr	Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
title_full_unstemmed	Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation
title_sort	electro-mechanical lung simulator using polymer and organic human lung equivalents for realistic breathing simulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ca20b7fcb4e4468db850a02f37ca040d
work_keys_str_mv	AT richardpasteka electromechanicallungsimulatorusingpolymerandorganichumanlungequivalentsforrealisticbreathingsimulation AT mathiasforjan electromechanicallungsimulatorusingpolymerandorganichumanlungequivalentsforrealisticbreathingsimulation AT stefansauermann electromechanicallungsimulatorusingpolymerandorganichumanlungequivalentsforrealisticbreathingsimulation AT andreasdrauschke electromechanicallungsimulatorusingpolymerandorganichumanlungequivalentsforrealisticbreathingsimulation
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Electro-mechanical Lung Simulator Using Polymer and Organic Human Lung Equivalents for Realistic Breathing Simulation

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