Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System

MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and impor...

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Autores principales:	Junyan Qu, Zhenghong Lin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	microRNAs E3 ubiquitin ligases deubiquitinases autophagy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ca20eaf1240247caafba0a875e28b53b
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id	oai:doaj.org-article:ca20eaf1240247caafba0a875e28b53b
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spelling	oai:doaj.org-article:ca20eaf1240247caafba0a875e28b53b2021-11-11T17:19:39ZAutophagy Regulation by Crosstalk between miRNAs and Ubiquitination System10.3390/ijms2221119121422-00671661-6596https://doaj.org/article/ca20eaf1240247caafba0a875e28b53b2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11912https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and important pathways in regulating protein degradation and signal transduction, in which E3 ubiquitin ligases and deubiquitinases (DUBs) play a decisive role. MiRNA and ubiquitination are involved in the regulation of most biological processes, including autophagy. Furthermore, in recent years, the direct interaction between miRNA and E3 ubiquitin ligases or deubiquitinases has attracted much attention, and the cross-talk between miRNA and ubiquitination system has been proved to play key regulatory roles in a variety of diseases. In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases.Junyan QuZhenghong LinMDPI AGarticlemicroRNAsE3 ubiquitin ligasesdeubiquitinasesautophagyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11912, p 11912 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNAs E3 ubiquitin ligases deubiquitinases autophagy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	microRNAs E3 ubiquitin ligases deubiquitinases autophagy Biology (General) QH301-705.5 Chemistry QD1-999 Junyan Qu Zhenghong Lin Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
description	MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules encoded by endogenous genes with ~22 nucleotides which are involved in the regulation of post-transcriptional gene expression. Ubiquitination and deubiquitination are common post-translational modifications in eukaryotic cells and important pathways in regulating protein degradation and signal transduction, in which E3 ubiquitin ligases and deubiquitinases (DUBs) play a decisive role. MiRNA and ubiquitination are involved in the regulation of most biological processes, including autophagy. Furthermore, in recent years, the direct interaction between miRNA and E3 ubiquitin ligases or deubiquitinases has attracted much attention, and the cross-talk between miRNA and ubiquitination system has been proved to play key regulatory roles in a variety of diseases. In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or deubiquitinases.
format	article
author	Junyan Qu Zhenghong Lin
author_facet	Junyan Qu Zhenghong Lin
author_sort	Junyan Qu
title	Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
title_short	Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
title_full	Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
title_fullStr	Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
title_full_unstemmed	Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System
title_sort	autophagy regulation by crosstalk between mirnas and ubiquitination system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca20eaf1240247caafba0a875e28b53b
work_keys_str_mv	AT junyanqu autophagyregulationbycrosstalkbetweenmirnasandubiquitinationsystem AT zhenghonglin autophagyregulationbycrosstalkbetweenmirnasandubiquitinationsystem
_version_	1718432144811884544

Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System

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