EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE

Objective: To evaluate the effect of a single dose of Ketamine in treatment of severe Major Depressive Disorder MDD in Pakistani patients. Study Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at Combined Military Hospital, Gilgit, from Apr 2017 to Mar 20...

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Autores principales:	Muhammad Siddique Kakar, Mansoor Mustafa, Haroon Khattak, Syed Khurram Naseer
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	ketamine major depressive disorder mdd nmda receptor Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca2213725744415f966b96f4ddbc4460
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spelling	oai:doaj.org-article:ca2213725744415f966b96f4ddbc44602021-12-02T17:18:34ZEFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE0030-96482411-8842https://doaj.org/article/ca2213725744415f966b96f4ddbc44602020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5559https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the effect of a single dose of Ketamine in treatment of severe Major Depressive Disorder MDD in Pakistani patients. Study Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at Combined Military Hospital, Gilgit, from Apr 2017 to Mar 2018. Methodology: Twenty nine subjects for this study had a primary diagnosis of severe Major Depressive disorder with a score of more than 19 on the HAM-D (Hamilton rating scale for depression) scale. These patients were divided into two groups. Group A received injection ketamine IV whereas group B received placebo 0.9% normal saline. Both were reassessed after 24 hours and there HAM-D scores were measured again. Results: Out of the total 29 patients, response was present in 14 (48.2%) and 15 (51.8%) did not respond to the treatment. Out of 19 patients that were treated with ketamine, 12 (63.1%) showed response to treatment while 7 (36.9%) did not respond. Out of 10 patients that were treated with placebo, 2 (20%) showed response to treatment while 8 (80%) did not respond. The p-value with a confidence interval of 95% was 0.033 showing that the difference in the two treatments was statistically significant. Conclusion: Ketamine demonstrated rapid antidepressant effects in this study, further supporting N-methyl-Daspartate (NMDA) receptor modulation as a novel mechanism for accelerated improvement in severe forms of depression. However further trials are needed to establish long term effects of the drug.Muhammad Siddique KakarMansoor MustafaHaroon KhattakSyed Khurram NaseerArmy Medical College Rawalpindiarticleketaminemajor depressive disorder mddnmda receptorMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1332-1336 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ketamine major depressive disorder mdd nmda receptor Medicine R Medicine (General) R5-920
spellingShingle	ketamine major depressive disorder mdd nmda receptor Medicine R Medicine (General) R5-920 Muhammad Siddique Kakar Mansoor Mustafa Haroon Khattak Syed Khurram Naseer EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
description	Objective: To evaluate the effect of a single dose of Ketamine in treatment of severe Major Depressive Disorder MDD in Pakistani patients. Study Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at Combined Military Hospital, Gilgit, from Apr 2017 to Mar 2018. Methodology: Twenty nine subjects for this study had a primary diagnosis of severe Major Depressive disorder with a score of more than 19 on the HAM-D (Hamilton rating scale for depression) scale. These patients were divided into two groups. Group A received injection ketamine IV whereas group B received placebo 0.9% normal saline. Both were reassessed after 24 hours and there HAM-D scores were measured again. Results: Out of the total 29 patients, response was present in 14 (48.2%) and 15 (51.8%) did not respond to the treatment. Out of 19 patients that were treated with ketamine, 12 (63.1%) showed response to treatment while 7 (36.9%) did not respond. Out of 10 patients that were treated with placebo, 2 (20%) showed response to treatment while 8 (80%) did not respond. The p-value with a confidence interval of 95% was 0.033 showing that the difference in the two treatments was statistically significant. Conclusion: Ketamine demonstrated rapid antidepressant effects in this study, further supporting N-methyl-Daspartate (NMDA) receptor modulation as a novel mechanism for accelerated improvement in severe forms of depression. However further trials are needed to establish long term effects of the drug.
format	article
author	Muhammad Siddique Kakar Mansoor Mustafa Haroon Khattak Syed Khurram Naseer
author_facet	Muhammad Siddique Kakar Mansoor Mustafa Haroon Khattak Syed Khurram Naseer
author_sort	Muhammad Siddique Kakar
title	EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
title_short	EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
title_full	EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
title_fullStr	EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
title_full_unstemmed	EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE
title_sort	effect of single dose of ketamine in patients of major depressive disorder-a pakistani perspective
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/ca2213725744415f966b96f4ddbc4460
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EFFECT OF SINGLE DOSE OF KETAMINE IN PATIENTS OF MAJOR DEPRESSIVE DISORDER-A PAKISTANI PERSPECTIVE

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