Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation
ABSTRACT Multiple pathogens, including viruses and bacteria, manipulate endoplasmic reticulum-associated degradation (ERAD) to avoid the host immune response and promote their replication. The betaretrovirus mouse mammary tumor virus (MMTV) encodes Rem, which is a precursor protein that is cleaved i...
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| Main Authors: | , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/ca2221265e544dcdb5eeb193ec2e290e |
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