New candidate blood biomarkers potentially associated with white matter hyperintensities progression

Abstract We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50–70, who underwent two magnetic resonanc...

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Autores principales:	Joan Jiménez-Balado, Jesús Pizarro, Iolanda Riba-Llena, Anna Penalba, Júlia Faura, Elena Palà, Joan Montaner, Mar Hernández-Guillamon, Pilar Delgado
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca2300f448bf4055a394bba09d82cfbc
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spelling	oai:doaj.org-article:ca2300f448bf4055a394bba09d82cfbc2021-12-02T16:14:09ZNew candidate blood biomarkers potentially associated with white matter hyperintensities progression10.1038/s41598-021-93498-w2045-2322https://doaj.org/article/ca2300f448bf4055a394bba09d82cfbc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93498-whttps://doaj.org/toc/2045-2322Abstract We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50–70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. In the discovery phase, we screened 1305 proteins in 12 subjects with WMH progression and in 12 matched control subjects. We found that 41 proteins were differentially expressed: 13 were upregulated and 28 were downregulated. We subsequently selected three biomarkers for replication in baseline and follow-up samples in 80 subjects with WMH progression and in 80 control subjects. The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growth factor receptor) and ASAH2 (neutral ceramidase), which were both lower in cases of WMH progression. Baseline biomarker concentrations did not predict WMH progression. In contrast, patients with WMH progression presented a steeper decline in MET over time. Furthermore, cases showed higher MMP9 and lower ASAH2 levels than controls at the follow-up. These results indicate that MMP9, MET, and ASAH2 are potentially associated with the progression of WMH, and could therefore be interesting candidates to validate in future studies.Joan Jiménez-BaladoJesús PizarroIolanda Riba-LlenaAnna PenalbaJúlia FauraElena PalàJoan MontanerMar Hernández-GuillamonPilar DelgadoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joan Jiménez-Balado Jesús Pizarro Iolanda Riba-Llena Anna Penalba Júlia Faura Elena Palà Joan Montaner Mar Hernández-Guillamon Pilar Delgado New candidate blood biomarkers potentially associated with white matter hyperintensities progression
description	Abstract We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50–70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. In the discovery phase, we screened 1305 proteins in 12 subjects with WMH progression and in 12 matched control subjects. We found that 41 proteins were differentially expressed: 13 were upregulated and 28 were downregulated. We subsequently selected three biomarkers for replication in baseline and follow-up samples in 80 subjects with WMH progression and in 80 control subjects. The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growth factor receptor) and ASAH2 (neutral ceramidase), which were both lower in cases of WMH progression. Baseline biomarker concentrations did not predict WMH progression. In contrast, patients with WMH progression presented a steeper decline in MET over time. Furthermore, cases showed higher MMP9 and lower ASAH2 levels than controls at the follow-up. These results indicate that MMP9, MET, and ASAH2 are potentially associated with the progression of WMH, and could therefore be interesting candidates to validate in future studies.
format	article
author	Joan Jiménez-Balado Jesús Pizarro Iolanda Riba-Llena Anna Penalba Júlia Faura Elena Palà Joan Montaner Mar Hernández-Guillamon Pilar Delgado
author_facet	Joan Jiménez-Balado Jesús Pizarro Iolanda Riba-Llena Anna Penalba Júlia Faura Elena Palà Joan Montaner Mar Hernández-Guillamon Pilar Delgado
author_sort	Joan Jiménez-Balado
title	New candidate blood biomarkers potentially associated with white matter hyperintensities progression
title_short	New candidate blood biomarkers potentially associated with white matter hyperintensities progression
title_full	New candidate blood biomarkers potentially associated with white matter hyperintensities progression
title_fullStr	New candidate blood biomarkers potentially associated with white matter hyperintensities progression
title_full_unstemmed	New candidate blood biomarkers potentially associated with white matter hyperintensities progression
title_sort	new candidate blood biomarkers potentially associated with white matter hyperintensities progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca2300f448bf4055a394bba09d82cfbc
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New candidate blood biomarkers potentially associated with white matter hyperintensities progression

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