Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

The permeabilization of the mitochondrial outer membrane to induce apoptosis is regulated by complex interactions between Bcl-2 family members. Here the authors develop a quantitative interactome of a membrane Bcl-2 network and identify a hierarchy of protein complexes in apoptosis induction.

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Main Authors:	Stephanie Bleicken, Annika Hantusch, Kushal Kumar Das, Tancred Frickey, Ana J. Garcia-Saez
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/ca24f04c17a149e2b6bbdd1ada2b7e7d
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spelling	oai:doaj.org-article:ca24f04c17a149e2b6bbdd1ada2b7e7d2021-12-02T14:16:04ZQuantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation10.1038/s41467-017-00086-62041-1723https://doaj.org/article/ca24f04c17a149e2b6bbdd1ada2b7e7d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00086-6https://doaj.org/toc/2041-1723The permeabilization of the mitochondrial outer membrane to induce apoptosis is regulated by complex interactions between Bcl-2 family members. Here the authors develop a quantitative interactome of a membrane Bcl-2 network and identify a hierarchy of protein complexes in apoptosis induction.Stephanie BleickenAnnika HantuschKushal Kumar DasTancred FrickeyAna J. Garcia-SaezNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephanie Bleicken Annika Hantusch Kushal Kumar Das Tancred Frickey Ana J. Garcia-Saez Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
description	The permeabilization of the mitochondrial outer membrane to induce apoptosis is regulated by complex interactions between Bcl-2 family members. Here the authors develop a quantitative interactome of a membrane Bcl-2 network and identify a hierarchy of protein complexes in apoptosis induction.
format	article
author	Stephanie Bleicken Annika Hantusch Kushal Kumar Das Tancred Frickey Ana J. Garcia-Saez
author_facet	Stephanie Bleicken Annika Hantusch Kushal Kumar Das Tancred Frickey Ana J. Garcia-Saez
author_sort	Stephanie Bleicken
title	Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
title_short	Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
title_full	Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
title_fullStr	Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
title_full_unstemmed	Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
title_sort	quantitative interactome of a membrane bcl-2 network identifies a hierarchy of complexes for apoptosis regulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ca24f04c17a149e2b6bbdd1ada2b7e7d
work_keys_str_mv	AT stephaniebleicken quantitativeinteractomeofamembranebcl2networkidentifiesahierarchyofcomplexesforapoptosisregulation AT annikahantusch quantitativeinteractomeofamembranebcl2networkidentifiesahierarchyofcomplexesforapoptosisregulation AT kushalkumardas quantitativeinteractomeofamembranebcl2networkidentifiesahierarchyofcomplexesforapoptosisregulation AT tancredfrickey quantitativeinteractomeofamembranebcl2networkidentifiesahierarchyofcomplexesforapoptosisregulation AT anajgarciasaez quantitativeinteractomeofamembranebcl2networkidentifiesahierarchyofcomplexesforapoptosisregulation
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Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation

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