The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital

Rationale: In the United States, non-tuberculous mycobacterium (NTM) infections are considered an important cause of morbidity and mortality, especially in people with progressive lung disease. The state of Florida has an extremely high incidence and prevalence of NTM disease which is likely a rapid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cristina V. Garcia, Greg E. Teo, Kristen Zeitler, Ripal Jariwala, Jose Montero, Beata Casanas, Sadaf Aslam, Anthony P. Cannella, Jamie P. Morano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Non-tuberculous Mycobacteria Epidemiology Central Florida Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/ca26614ae4a943a79224db66ba041719
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca26614ae4a943a79224db66ba041719
record_format	dspace
spelling	oai:doaj.org-article:ca26614ae4a943a79224db66ba0417192021-11-26T04:35:21ZThe epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital2405-579410.1016/j.jctube.2021.100289https://doaj.org/article/ca26614ae4a943a79224db66ba0417192021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405579421000784https://doaj.org/toc/2405-5794Rationale: In the United States, non-tuberculous mycobacterium (NTM) infections are considered an important cause of morbidity and mortality, especially in people with progressive lung disease. The state of Florida has an extremely high incidence and prevalence of NTM disease which is likely a rapidly emerging infection in the state due to environmental and demographic factors. Objectives: Adjemian et al. [1] To determine the burden of NTM disease of patients admitted to a large Central Florida academic center, Falkinham [2] to identify the most common risk factors associated with developing NTM disease in this area, and Sfeir et al. [4] to categorize antimicrobial susceptibilities and genetic resistance markers. Methods: We conducted a retrospective case review from January 1, 2011 to December 31, 2017 in a large university-associated metropolitan hospital in west-central Florida. NTM infections were identified using TheraDoc® during the study period with the inclusion criteria of any inpatient admission, culture confirmed NTM at any site, and age ≥ 12 years. Demographic variables (including residential zip code) and comorbidity data (including solid organ transplant status, HIV status and subsequent testing results, intrinsic pulmonary disease, and cancer diagnosis of any site) were collected for each patient. Microbiologic data collected included NTM species/subspecies, anatomic location of specimen collection, antimicrobial susceptibility including minimum inhibitory concentration (MIC). All collected data were analyzed within Stata/IC14.2. Geospatial relationships between zip codes, diagnosis type, and co-morbidities were computed using Arc GIS Pro. Results: Our results demonstrated that a substantial number of our inpatient cases with NTM were of the M. abscessus group, and with M. avium complex and M. fortuitum also representing the pathogen in numerous cases. Novel findings included compilation of the first hospital wide comprehensive NTM resistance plot to our knowledge. Our results did show a concordance with previous data with expected predominance of NTM inpatient cases in Caucasian males with pre-existing pulmonary disease, though additional work could be done with isolates within the transplant and immunosuppressed populations. Conclusions: Our data set demonstrates the most common species/subspecies of NTM infections and their associated conditions seen at our central Florida hospital, and includes an antimicrobial sensitivity analysis in toto. This could be insight into the possible prevalence of NTM in the area, and provides the foundation for future studies on both the acquisition and prevention for NTM infections in central Florida.Cristina V. GarciaGreg E. TeoKristen ZeitlerRipal JariwalaJose MonteroBeata CasanasSadaf AslamAnthony P. CannellaJamie P. MoranoElsevierarticleNon-tuberculous MycobacteriaEpidemiologyCentral FloridaDiseases of the respiratory systemRC705-779Infectious and parasitic diseasesRC109-216ENJournal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 25, Iss , Pp 100289- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-tuberculous Mycobacteria Epidemiology Central Florida Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216
spellingShingle	Non-tuberculous Mycobacteria Epidemiology Central Florida Diseases of the respiratory system RC705-779 Infectious and parasitic diseases RC109-216 Cristina V. Garcia Greg E. Teo Kristen Zeitler Ripal Jariwala Jose Montero Beata Casanas Sadaf Aslam Anthony P. Cannella Jamie P. Morano The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
description	Rationale: In the United States, non-tuberculous mycobacterium (NTM) infections are considered an important cause of morbidity and mortality, especially in people with progressive lung disease. The state of Florida has an extremely high incidence and prevalence of NTM disease which is likely a rapidly emerging infection in the state due to environmental and demographic factors. Objectives: Adjemian et al. [1] To determine the burden of NTM disease of patients admitted to a large Central Florida academic center, Falkinham [2] to identify the most common risk factors associated with developing NTM disease in this area, and Sfeir et al. [4] to categorize antimicrobial susceptibilities and genetic resistance markers. Methods: We conducted a retrospective case review from January 1, 2011 to December 31, 2017 in a large university-associated metropolitan hospital in west-central Florida. NTM infections were identified using TheraDoc® during the study period with the inclusion criteria of any inpatient admission, culture confirmed NTM at any site, and age ≥ 12 years. Demographic variables (including residential zip code) and comorbidity data (including solid organ transplant status, HIV status and subsequent testing results, intrinsic pulmonary disease, and cancer diagnosis of any site) were collected for each patient. Microbiologic data collected included NTM species/subspecies, anatomic location of specimen collection, antimicrobial susceptibility including minimum inhibitory concentration (MIC). All collected data were analyzed within Stata/IC14.2. Geospatial relationships between zip codes, diagnosis type, and co-morbidities were computed using Arc GIS Pro. Results: Our results demonstrated that a substantial number of our inpatient cases with NTM were of the M. abscessus group, and with M. avium complex and M. fortuitum also representing the pathogen in numerous cases. Novel findings included compilation of the first hospital wide comprehensive NTM resistance plot to our knowledge. Our results did show a concordance with previous data with expected predominance of NTM inpatient cases in Caucasian males with pre-existing pulmonary disease, though additional work could be done with isolates within the transplant and immunosuppressed populations. Conclusions: Our data set demonstrates the most common species/subspecies of NTM infections and their associated conditions seen at our central Florida hospital, and includes an antimicrobial sensitivity analysis in toto. This could be insight into the possible prevalence of NTM in the area, and provides the foundation for future studies on both the acquisition and prevention for NTM infections in central Florida.
format	article
author	Cristina V. Garcia Greg E. Teo Kristen Zeitler Ripal Jariwala Jose Montero Beata Casanas Sadaf Aslam Anthony P. Cannella Jamie P. Morano
author_facet	Cristina V. Garcia Greg E. Teo Kristen Zeitler Ripal Jariwala Jose Montero Beata Casanas Sadaf Aslam Anthony P. Cannella Jamie P. Morano
author_sort	Cristina V. Garcia
title	The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
title_short	The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
title_full	The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
title_fullStr	The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
title_full_unstemmed	The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital
title_sort	epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central florida academic hospital
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ca26614ae4a943a79224db66ba041719
work_keys_str_mv	AT cristinavgarcia theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT gregeteo theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT kristenzeitler theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT ripaljariwala theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT josemontero theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT beatacasanas theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT sadafaslam theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT anthonypcannella theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT jamiepmorano theepidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT cristinavgarcia epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT gregeteo epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT kristenzeitler epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT ripaljariwala epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT josemontero epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT beatacasanas epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT sadafaslam epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT anthonypcannella epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital AT jamiepmorano epidemiologydemographicsandcomorbiditiesofpulmonaryandextrapulmonarynontuberculousmycobacterialinfectionsatalargecentralfloridaacademichospital
_version_	1718409867069227008

The epidemiology, demographics, and comorbidities of pulmonary and extra-pulmonary non-tuberculous mycobacterial infections at a large central Florida Academic Hospital

Ejemplares similares