High particle variability across siliconized and oil-free syringes and needles from the same lots

Abstract Previous studies have reported silicone oil (SO) applied to needles and syringes in the vitreous of patients after intravitreal injections. We evaluated four syringes (SR 1-mL insulin, Saldanha-Rodrigues; BD 1-mL Tuberculin Slip Tip, Becton–Dickinson; BD Ultra-Fine 0.3 mL, HSW Norm-Ject Tub...

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Autores principales:	Lydianne Lumack do Monte Agra, Natasha Ferreira Santos da Cruz, Vaida Linkuviene, John F. Carpenter, Michel Eid Farah, Gustavo Barreto Melo, Maurício Maia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca280611157a482a9e6e6b7b5bccca36
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spelling	oai:doaj.org-article:ca280611157a482a9e6e6b7b5bccca362021-12-02T15:53:46ZHigh particle variability across siliconized and oil-free syringes and needles from the same lots10.1038/s41598-021-84158-02045-2322https://doaj.org/article/ca280611157a482a9e6e6b7b5bccca362021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84158-0https://doaj.org/toc/2045-2322Abstract Previous studies have reported silicone oil (SO) applied to needles and syringes in the vitreous of patients after intravitreal injections. We evaluated four syringes (SR 1-mL insulin, Saldanha-Rodrigues; BD 1-mL Tuberculin Slip Tip, Becton–Dickinson; BD Ultra-Fine 0.3 mL, HSW Norm-Ject Tuberculin, Henke Sass Wolf) and 10 needles (BD PrecisionGlide 27- and 30-gauge (G); BD Eclipse and JBP Nanoneedle 27-, 30-, 33- and 34-G; TSK Invisible Needle and 27 and 30-G Steriject Control Hub). The protein-free buffer samples injected into the syringes and needles under study were collected in an Eppendorf tube and taken to Flow imaging microscopy, that characterized the concentration and morphology of the microsized particles. The number of particles was analyzed. The coefficients of variation (CV) were the primary outcome. The Feltz and Miller test compared the CVs. The significance level was 5%. Numerous particles and high CVs were associated with both devices, needles and syringes; the comparisons among them did not reach significance. The BD Ultrafine 0.3 mL syringe (149.7%) had the highest CV and the SO-free HSW Norm-Ject (66.4%) syringe the lowest, and the TSK Invisible needle (149.5%) had the highest and the BD Precision Glide 30G needle (35.9%) needle the lowest. In conclusion, particle release, including those with SO morphology, varied greatly among instruments, even from the same lots, which is relevant considering that fewer particles are injected into some eyes compared with others.Lydianne Lumack do Monte AgraNatasha Ferreira Santos da CruzVaida LinkuvieneJohn F. CarpenterMichel Eid FarahGustavo Barreto MeloMaurício MaiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lydianne Lumack do Monte Agra Natasha Ferreira Santos da Cruz Vaida Linkuviene John F. Carpenter Michel Eid Farah Gustavo Barreto Melo Maurício Maia High particle variability across siliconized and oil-free syringes and needles from the same lots
description	Abstract Previous studies have reported silicone oil (SO) applied to needles and syringes in the vitreous of patients after intravitreal injections. We evaluated four syringes (SR 1-mL insulin, Saldanha-Rodrigues; BD 1-mL Tuberculin Slip Tip, Becton–Dickinson; BD Ultra-Fine 0.3 mL, HSW Norm-Ject Tuberculin, Henke Sass Wolf) and 10 needles (BD PrecisionGlide 27- and 30-gauge (G); BD Eclipse and JBP Nanoneedle 27-, 30-, 33- and 34-G; TSK Invisible Needle and 27 and 30-G Steriject Control Hub). The protein-free buffer samples injected into the syringes and needles under study were collected in an Eppendorf tube and taken to Flow imaging microscopy, that characterized the concentration and morphology of the microsized particles. The number of particles was analyzed. The coefficients of variation (CV) were the primary outcome. The Feltz and Miller test compared the CVs. The significance level was 5%. Numerous particles and high CVs were associated with both devices, needles and syringes; the comparisons among them did not reach significance. The BD Ultrafine 0.3 mL syringe (149.7%) had the highest CV and the SO-free HSW Norm-Ject (66.4%) syringe the lowest, and the TSK Invisible needle (149.5%) had the highest and the BD Precision Glide 30G needle (35.9%) needle the lowest. In conclusion, particle release, including those with SO morphology, varied greatly among instruments, even from the same lots, which is relevant considering that fewer particles are injected into some eyes compared with others.
format	article
author	Lydianne Lumack do Monte Agra Natasha Ferreira Santos da Cruz Vaida Linkuviene John F. Carpenter Michel Eid Farah Gustavo Barreto Melo Maurício Maia
author_facet	Lydianne Lumack do Monte Agra Natasha Ferreira Santos da Cruz Vaida Linkuviene John F. Carpenter Michel Eid Farah Gustavo Barreto Melo Maurício Maia
author_sort	Lydianne Lumack do Monte Agra
title	High particle variability across siliconized and oil-free syringes and needles from the same lots
title_short	High particle variability across siliconized and oil-free syringes and needles from the same lots
title_full	High particle variability across siliconized and oil-free syringes and needles from the same lots
title_fullStr	High particle variability across siliconized and oil-free syringes and needles from the same lots
title_full_unstemmed	High particle variability across siliconized and oil-free syringes and needles from the same lots
title_sort	high particle variability across siliconized and oil-free syringes and needles from the same lots
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca280611157a482a9e6e6b7b5bccca36
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High particle variability across siliconized and oil-free syringes and needles from the same lots

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