Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease

Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed c...

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Autores principales:	Christine Loftis, Emilia C. Dulgheru, Rosa White
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/ca281f0ad67e463cb5fadaa1d470067c
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spelling	oai:doaj.org-article:ca281f0ad67e463cb5fadaa1d470067c2021-11-29T00:55:30ZAcquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease2090-689710.1155/2021/3666270https://doaj.org/article/ca281f0ad67e463cb5fadaa1d470067c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3666270https://doaj.org/toc/2090-6897Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed connective tissue disease. This article includes a literature review of pregnancy-related cases of acquired factor VIII deficiency. We also reviewed various therapeutic approaches for the management of the acquired factor inhibitor which include achieving hemostasis and elimination of the inhibitor via immunosuppressive agents. This case report describes the rare presentation of acquired factor VIII deficiency related to pregnancy and highlights the importance of considering a factor VIII inhibitor in the differential diagnosis of patients who present with bleeding and prolonged PTT during the peripartum and postpartum periods.Christine LoftisEmilia C. DulgheruRosa WhiteHindawi LimitedarticleDiseases of the musculoskeletal systemRC925-935ENCase Reports in Rheumatology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Christine Loftis Emilia C. Dulgheru Rosa White Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
description	Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed connective tissue disease. This article includes a literature review of pregnancy-related cases of acquired factor VIII deficiency. We also reviewed various therapeutic approaches for the management of the acquired factor inhibitor which include achieving hemostasis and elimination of the inhibitor via immunosuppressive agents. This case report describes the rare presentation of acquired factor VIII deficiency related to pregnancy and highlights the importance of considering a factor VIII inhibitor in the differential diagnosis of patients who present with bleeding and prolonged PTT during the peripartum and postpartum periods.
format	article
author	Christine Loftis Emilia C. Dulgheru Rosa White
author_facet	Christine Loftis Emilia C. Dulgheru Rosa White
author_sort	Christine Loftis
title	Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
title_short	Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
title_full	Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
title_fullStr	Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
title_full_unstemmed	Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease
title_sort	acquired factor viii deficiency presenting as gross hematuria in a hispanic, pregnant patient with previously undiagnosed connective tissue disease
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/ca281f0ad67e463cb5fadaa1d470067c
work_keys_str_mv	AT christineloftis acquiredfactorviiideficiencypresentingasgrosshematuriainahispanicpregnantpatientwithpreviouslyundiagnosedconnectivetissuedisease AT emiliacdulgheru acquiredfactorviiideficiencypresentingasgrosshematuriainahispanicpregnantpatientwithpreviouslyundiagnosedconnectivetissuedisease AT rosawhite acquiredfactorviiideficiencypresentingasgrosshematuriainahispanicpregnantpatientwithpreviouslyundiagnosedconnectivetissuedisease
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Acquired Factor VIII Deficiency Presenting as Gross Hematuria in a Hispanic, Pregnant Patient with Previously Undiagnosed Connective Tissue Disease

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