Preclinical Investigation of Goniotomy Using Four Different Techniques

David A Ammar,1 Leonard K Seibold,2 Malik Y Kahook2 1Research Department, Lions Eye Institute for Transplant & Research, Tampa, FL, USA; 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USACorrespondence: Malik Y KahookUniversity of Colorado School of Medi...

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Autores principales:	Ammar DA, Seibold LK, Kahook MY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	glaucoma goniotomy trabecular meshwork Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ca2841d102fc473a80bc14b15b66c2d3
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spelling	oai:doaj.org-article:ca2841d102fc473a80bc14b15b66c2d32021-12-02T10:22:49ZPreclinical Investigation of Goniotomy Using Four Different Techniques1177-5483https://doaj.org/article/ca2841d102fc473a80bc14b15b66c2d32020-10-01T00:00:00Zhttps://www.dovepress.com/preclinical-investigation-of-goniotomy-using-four-different-techniques-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483David A Ammar,1 Leonard K Seibold,2 Malik Y Kahook2 1Research Department, Lions Eye Institute for Transplant & Research, Tampa, FL, USA; 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USACorrespondence: Malik Y KahookUniversity of Colorado School of Medicine, 1675 Aurora Ct, Aurora, CO 80045, USATel +1 720 848 2500Fax +1 720 848 5014Email malik.kahook@cuanschutz.eduPurpose: To evaluate the tissue-level effects of goniotomy techniques on human trabecular meshwork (TM).Design: Laboratory investigation.Methods: The TM from human cadaveric corneal rim tissue was treated using 4 techniques: (1) microvitreoretinal (MVR) blade; (2) 360° trabeculotomy with 5-0 prolene suture; (3) the Kahook Dual Blade (KDB) Glide® device; (4) TrabEx™ device; tissue samples underwent standard histologic processing with H&E stain followed by comparative analyses.Results: The MVR blade exhibited incision of TM extending into the scleral wall. The TrabEx device removed a small portion of TM with large leaflet tissue remnants in all treated areas. 360° suture trabeculotomy resulted in incision of the TM proximate to Schwalbe’s line with no excised tissue evident in all treated areas. Areas treated with the KDB Glide device resulted in nearly complete excision of TM without injury to surrounding tissues.Conclusion: The various methods used for performing goniotomy or trabeculotomy resulted in varying degrees of incision or excision of TM. Only the KDB Glide device resulted in reliable excision of TM with the other devices producing incision or variable excision of tissue. Clinical correlation is required to better understand the implications of the current findings when using these methods to lower intraocular pressure in eyes with glaucoma.Keywords: glaucoma, goniotomy, trabecular meshworkAmmar DASeibold LKKahook MYDove Medical Pressarticleglaucomagoniotomytrabecular meshworkOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 3519-3525 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma goniotomy trabecular meshwork Ophthalmology RE1-994
spellingShingle	glaucoma goniotomy trabecular meshwork Ophthalmology RE1-994 Ammar DA Seibold LK Kahook MY Preclinical Investigation of Goniotomy Using Four Different Techniques
description	David A Ammar,1 Leonard K Seibold,2 Malik Y Kahook2 1Research Department, Lions Eye Institute for Transplant & Research, Tampa, FL, USA; 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USACorrespondence: Malik Y KahookUniversity of Colorado School of Medicine, 1675 Aurora Ct, Aurora, CO 80045, USATel +1 720 848 2500Fax +1 720 848 5014Email malik.kahook@cuanschutz.eduPurpose: To evaluate the tissue-level effects of goniotomy techniques on human trabecular meshwork (TM).Design: Laboratory investigation.Methods: The TM from human cadaveric corneal rim tissue was treated using 4 techniques: (1) microvitreoretinal (MVR) blade; (2) 360° trabeculotomy with 5-0 prolene suture; (3) the Kahook Dual Blade (KDB) Glide® device; (4) TrabEx™ device; tissue samples underwent standard histologic processing with H&E stain followed by comparative analyses.Results: The MVR blade exhibited incision of TM extending into the scleral wall. The TrabEx device removed a small portion of TM with large leaflet tissue remnants in all treated areas. 360° suture trabeculotomy resulted in incision of the TM proximate to Schwalbe’s line with no excised tissue evident in all treated areas. Areas treated with the KDB Glide device resulted in nearly complete excision of TM without injury to surrounding tissues.Conclusion: The various methods used for performing goniotomy or trabeculotomy resulted in varying degrees of incision or excision of TM. Only the KDB Glide device resulted in reliable excision of TM with the other devices producing incision or variable excision of tissue. Clinical correlation is required to better understand the implications of the current findings when using these methods to lower intraocular pressure in eyes with glaucoma.Keywords: glaucoma, goniotomy, trabecular meshwork
format	article
author	Ammar DA Seibold LK Kahook MY
author_facet	Ammar DA Seibold LK Kahook MY
author_sort	Ammar DA
title	Preclinical Investigation of Goniotomy Using Four Different Techniques
title_short	Preclinical Investigation of Goniotomy Using Four Different Techniques
title_full	Preclinical Investigation of Goniotomy Using Four Different Techniques
title_fullStr	Preclinical Investigation of Goniotomy Using Four Different Techniques
title_full_unstemmed	Preclinical Investigation of Goniotomy Using Four Different Techniques
title_sort	preclinical investigation of goniotomy using four different techniques
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/ca2841d102fc473a80bc14b15b66c2d3
work_keys_str_mv	AT ammarda preclinicalinvestigationofgoniotomyusingfourdifferenttechniques AT seiboldlk preclinicalinvestigationofgoniotomyusingfourdifferenttechniques AT kahookmy preclinicalinvestigationofgoniotomyusingfourdifferenttechniques
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Preclinical Investigation of Goniotomy Using Four Different Techniques

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