A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be use...

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Autores principales: Jing-Rong Wang, Wei-Na Gao, Rudolf Grimm, Shibo Jiang, Yong Liang, Hua Ye, Zhan-Guo Li, Lee-Fong Yau, Hao Huang, Ju Liu, Min Jiang, Qiong Meng, Tian-Tian Tong, Hai-Hui Huang, Stephanie Lee, Xing Zeng, Liang Liu, Zhi-Hong Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ca2ca638cde14bb8b892f0ac694cda79
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spelling oai:doaj.org-article:ca2ca638cde14bb8b892f0ac694cda792021-12-02T17:05:59ZA method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis10.1038/s41467-017-00662-w2041-1723https://doaj.org/article/ca2ca638cde14bb8b892f0ac694cda792017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00662-whttps://doaj.org/toc/2041-1723Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be used as biomarkers for rheumatoid arthritis.Jing-Rong WangWei-Na GaoRudolf GrimmShibo JiangYong LiangHua YeZhan-Guo LiLee-Fong YauHao HuangJu LiuMin JiangQiong MengTian-Tian TongHai-Hui HuangStephanie LeeXing ZengLiang LiuZhi-Hong JiangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jing-Rong Wang
Wei-Na Gao
Rudolf Grimm
Shibo Jiang
Yong Liang
Hua Ye
Zhan-Guo Li
Lee-Fong Yau
Hao Huang
Ju Liu
Min Jiang
Qiong Meng
Tian-Tian Tong
Hai-Hui Huang
Stephanie Lee
Xing Zeng
Liang Liu
Zhi-Hong Jiang
A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
description Post-translational modifications can affect antibody function in health and disease, but identification of all variants is difficult using existing technologies. Here the authors develop a microfluidic method to identify and quantify low-abundance IgG N-glycans and show some of these IgGs can be used as biomarkers for rheumatoid arthritis.
format article
author Jing-Rong Wang
Wei-Na Gao
Rudolf Grimm
Shibo Jiang
Yong Liang
Hua Ye
Zhan-Guo Li
Lee-Fong Yau
Hao Huang
Ju Liu
Min Jiang
Qiong Meng
Tian-Tian Tong
Hai-Hui Huang
Stephanie Lee
Xing Zeng
Liang Liu
Zhi-Hong Jiang
author_facet Jing-Rong Wang
Wei-Na Gao
Rudolf Grimm
Shibo Jiang
Yong Liang
Hua Ye
Zhan-Guo Li
Lee-Fong Yau
Hao Huang
Ju Liu
Min Jiang
Qiong Meng
Tian-Tian Tong
Hai-Hui Huang
Stephanie Lee
Xing Zeng
Liang Liu
Zhi-Hong Jiang
author_sort Jing-Rong Wang
title A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
title_short A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
title_full A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
title_fullStr A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
title_full_unstemmed A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis
title_sort method to identify trace sulfated igg n-glycans as biomarkers for rheumatoid arthritis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ca2ca638cde14bb8b892f0ac694cda79
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