Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study

Background The linear association between median age at cancer onset and median age of the underlying population has been described only for breast cancer. We quantified the shape and strength of such association for 20 cancer types using data from all population-based cancer registries (CRs) worldw...

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Autores principales:	Ettore Bidoli, Elda Lamaj, Tiziana Angelin, Ornella Forgiarini, Emilia De Santis, Diego Serraino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer incidence age at onset population pyramid worldwide 25-year Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ca2ca99f1751419eb0e0299c490b75bc
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spelling	oai:doaj.org-article:ca2ca99f1751419eb0e0299c490b75bc2021-11-11T15:36:19ZLinearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study10.3390/cancers132155892072-6694https://doaj.org/article/ca2ca99f1751419eb0e0299c490b75bc2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5589https://doaj.org/toc/2072-6694Background The linear association between median age at cancer onset and median age of the underlying population has been described only for breast cancer. We quantified the shape and strength of such association for 20 cancer types using data from all population-based cancer registries (CRs) worldwide. Methods The patients’ median age at cancer onset and of the underlying population were extracted from all CRs listed in volumes VI (1983–1987 years) and XI (2008–2012 years) of Cancer Incidence in Five Continents. The association was assessed at cross-sectional level by linear regression models and longitudinally considering only the long-standing CRs active throughout the study period (i.e., 25-year span). Results During 2008–2012, each one-year increase in median population ageing was associated in men with a nearly half year increase of median age at onset of all cancers, but skin; and a 2/3 year increase in women. Variance explained by linear model was around 60%. In long-standing CRs a decrease in median age at cancer onset was observed for prostate and cervical cancers throughout the 25-year span. Conclusions Population ageing reflected 60% of the median age at cancer onset. Misinterpretation of peaks of cancer incidence in specific age groups may be avoided by examining population pyramids.Ettore BidoliElda LamajTiziana AngelinOrnella ForgiariniEmilia De SantisDiego SerrainoMDPI AGarticlecancerincidenceage at onsetpopulation pyramidworldwide25-yearNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5589, p 5589 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer incidence age at onset population pyramid worldwide 25-year Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer incidence age at onset population pyramid worldwide 25-year Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ettore Bidoli Elda Lamaj Tiziana Angelin Ornella Forgiarini Emilia De Santis Diego Serraino Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
description	Background The linear association between median age at cancer onset and median age of the underlying population has been described only for breast cancer. We quantified the shape and strength of such association for 20 cancer types using data from all population-based cancer registries (CRs) worldwide. Methods The patients’ median age at cancer onset and of the underlying population were extracted from all CRs listed in volumes VI (1983–1987 years) and XI (2008–2012 years) of Cancer Incidence in Five Continents. The association was assessed at cross-sectional level by linear regression models and longitudinally considering only the long-standing CRs active throughout the study period (i.e., 25-year span). Results During 2008–2012, each one-year increase in median population ageing was associated in men with a nearly half year increase of median age at onset of all cancers, but skin; and a 2/3 year increase in women. Variance explained by linear model was around 60%. In long-standing CRs a decrease in median age at cancer onset was observed for prostate and cervical cancers throughout the 25-year span. Conclusions Population ageing reflected 60% of the median age at cancer onset. Misinterpretation of peaks of cancer incidence in specific age groups may be avoided by examining population pyramids.
format	article
author	Ettore Bidoli Elda Lamaj Tiziana Angelin Ornella Forgiarini Emilia De Santis Diego Serraino
author_facet	Ettore Bidoli Elda Lamaj Tiziana Angelin Ornella Forgiarini Emilia De Santis Diego Serraino
author_sort	Ettore Bidoli
title	Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
title_short	Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
title_full	Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
title_fullStr	Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
title_full_unstemmed	Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study
title_sort	linearity of age at cancer onset worldwide: 25-year population-based cancer registry study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca2ca99f1751419eb0e0299c490b75bc
work_keys_str_mv	AT ettorebidoli linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy AT eldalamaj linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy AT tizianaangelin linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy AT ornellaforgiarini linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy AT emiliadesantis linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy AT diegoserraino linearityofageatcanceronsetworldwide25yearpopulationbasedcancerregistrystudy
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Linearity of Age at Cancer Onset Worldwide: 25-Year Population-Based Cancer Registry Study

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