Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial

Background: Deficits in associative memory (AM) are the earliest and most prominent feature of Alzheimer's disease (AD) and demonstrate a clear cause of distress for patients and their families. Objective: The present study aimed to determine AM enhancements following accelerated intermittent t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xingqi Wu, Gong-Jun Ji, Zhi Geng, Lu Wang, Yibing Yan, Yue Wu, Guixian Xiao, Liying Gao, Qiang Wei, Shanshan Zhou, Ling Wei, Yanghua Tian, Kai Wang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Transcranial magnetic stimulation Intermittent theta-burst stimulation Alzheimer's disease Cognition enhancement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/ca2dbc72384348389229e08cb4228cdd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca2dbc72384348389229e08cb4228cdd
record_format	dspace
spelling	oai:doaj.org-article:ca2dbc72384348389229e08cb4228cdd2021-11-10T04:22:41ZAccelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial1935-861X10.1016/j.brs.2021.11.007https://doaj.org/article/ca2dbc72384348389229e08cb4228cdd2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1935861X21008056https://doaj.org/toc/1935-861XBackground: Deficits in associative memory (AM) are the earliest and most prominent feature of Alzheimer's disease (AD) and demonstrate a clear cause of distress for patients and their families. Objective: The present study aimed to determine AM enhancements following accelerated intermittent theta-burst stimulation (iTBS) in patients with AD. Methods: In a randomized, double-blind, sham-controlled design, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of patients with AD for 14 days. Measurements included AM (primary outcome) and a comprehensive neuropsychological battery. Patients were evaluated at baseline, following the intervention (week 2), and 8 weeks after treatment cessation (week 10). Results: Sixty patients with AD were initially enrolled; 47 completed the trial. The active group displayed greater AM improvements compared with the sham group at week 2 (P = 0.003), which was sustained at week 10. Furthermore, higher Mini-Mental State Examination (MMSE) scores at baseline were associated with greater AM improvements at weeks 2 and 10. For the independent iTBS group, this correlation predicted improvements in AM (P < 0.001) and identified treatment responders with 92% accuracy. Most of the neuropsychological tests were markedly improved in the active group. In particular, the Montreal Cognitive Assessment and MMSE in the active group increased by 2.8 and 2.3 points, respectively, at week 2, while there was no marked change in the sham group. Conclusion: In the present study, accelerated iTBS of the DLPFC demonstrated an effective and well-tolerated complementary treatment for patients with AD, especially for individuals with relatively high MMSE scores.Xingqi WuGong-Jun JiZhi GengLu WangYibing YanYue WuGuixian XiaoLiying GaoQiang WeiShanshan ZhouLing WeiYanghua TianKai WangElsevierarticleTranscranial magnetic stimulationIntermittent theta-burst stimulationAlzheimer's diseaseCognition enhancementNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Stimulation, Vol 15, Iss 1, Pp 35-45 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transcranial magnetic stimulation Intermittent theta-burst stimulation Alzheimer's disease Cognition enhancement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Transcranial magnetic stimulation Intermittent theta-burst stimulation Alzheimer's disease Cognition enhancement Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xingqi Wu Gong-Jun Ji Zhi Geng Lu Wang Yibing Yan Yue Wu Guixian Xiao Liying Gao Qiang Wei Shanshan Zhou Ling Wei Yanghua Tian Kai Wang Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
description	Background: Deficits in associative memory (AM) are the earliest and most prominent feature of Alzheimer's disease (AD) and demonstrate a clear cause of distress for patients and their families. Objective: The present study aimed to determine AM enhancements following accelerated intermittent theta-burst stimulation (iTBS) in patients with AD. Methods: In a randomized, double-blind, sham-controlled design, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of patients with AD for 14 days. Measurements included AM (primary outcome) and a comprehensive neuropsychological battery. Patients were evaluated at baseline, following the intervention (week 2), and 8 weeks after treatment cessation (week 10). Results: Sixty patients with AD were initially enrolled; 47 completed the trial. The active group displayed greater AM improvements compared with the sham group at week 2 (P = 0.003), which was sustained at week 10. Furthermore, higher Mini-Mental State Examination (MMSE) scores at baseline were associated with greater AM improvements at weeks 2 and 10. For the independent iTBS group, this correlation predicted improvements in AM (P < 0.001) and identified treatment responders with 92% accuracy. Most of the neuropsychological tests were markedly improved in the active group. In particular, the Montreal Cognitive Assessment and MMSE in the active group increased by 2.8 and 2.3 points, respectively, at week 2, while there was no marked change in the sham group. Conclusion: In the present study, accelerated iTBS of the DLPFC demonstrated an effective and well-tolerated complementary treatment for patients with AD, especially for individuals with relatively high MMSE scores.
format	article
author	Xingqi Wu Gong-Jun Ji Zhi Geng Lu Wang Yibing Yan Yue Wu Guixian Xiao Liying Gao Qiang Wei Shanshan Zhou Ling Wei Yanghua Tian Kai Wang
author_facet	Xingqi Wu Gong-Jun Ji Zhi Geng Lu Wang Yibing Yan Yue Wu Guixian Xiao Liying Gao Qiang Wei Shanshan Zhou Ling Wei Yanghua Tian Kai Wang
author_sort	Xingqi Wu
title	Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
title_short	Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
title_full	Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
title_fullStr	Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
title_full_unstemmed	Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial
title_sort	accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in alzheimer's disease: a randomized controlled trial
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/ca2dbc72384348389229e08cb4228cdd
work_keys_str_mv	AT xingqiwu acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT gongjunji acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT zhigeng acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT luwang acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT yibingyan acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT yuewu acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT guixianxiao acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT liyinggao acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT qiangwei acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT shanshanzhou acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT lingwei acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT yanghuatian acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial AT kaiwang acceleratedintermittentthetaburststimulationbroadlyamelioratessymptomsandcognitioninalzheimersdiseasearandomizedcontrolledtrial
_version_	1718440692394491904

Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial

Ejemplares similares